Sex differences in outcomes after acute coronary syndrome vary with age: a New Zealand national study

This study investigated age-specific sex differences in short- and long-term clinical outcomes following hospitalization for a first-time acute coronary syndrome (ACS) in New Zealand (NZ). Using linked national health datasets, people admitted to hospital for a first-time ACS between January 2010 an...

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Published in:European heart journal. Acute cardiovascular care 2024-03, Vol.13 (3), p.284-292
Main Authors: Earle, Nikki J, Doughty, Robert N, Devlin, Gerry, White, Harvey, Riddell, Craig, Choi, Yeunhyang, Kerr, Andrew J, Poppe, Katrina K
Format: Article
Language:English
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Summary:This study investigated age-specific sex differences in short- and long-term clinical outcomes following hospitalization for a first-time acute coronary syndrome (ACS) in New Zealand (NZ). Using linked national health datasets, people admitted to hospital for a first-time ACS between January 2010 and December 2016 were included. Analyses were stratified by sex and 10-year age groups. Logistic and Cox regression were used to assess in-hospital death and from discharge the primary outcome of time to first cardiovascular (CV) readmission or death and other secondary outcomes at 30 days and 2 years. Among 63 245 people (mean age 69 years, 40% women), women were older than men at the time of the ACS admission (mean age 73 vs. 66 years), with a higher comorbidity burden. Overall compared with men, women experienced higher rates of unadjusted in-hospital death (10% vs. 7%), 30-day (16% vs. 12%) and 2-year (44% vs. 34%) death, or CV readmission (all P < 0.001). Age group-specific analyses showed sex differences in outcomes varied with age, with younger women (
ISSN:2048-8726
2048-8734
DOI:10.1093/ehjacc/zuad151