Non-alcoholic fatty liver disease prevalence in Australia has risen over 15 years in conjunction with increased prevalence of obesity and reduction in healthy lifestyle

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition globally. The aim of this study was to evaluate the change in age- and sex-standardized prevalence of NAFLD in regional Victoria over a 15-year period and explore the underlying factors associated with differences over t...

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Published in:Journal of gastroenterology and hepatology 2023-10, Vol.38 (10), p.1823-1831
Main Authors: Vaz, Karl, Kemp, William, Majeed, Ammar, Lubel, John, Magliano, Dianna J, Glenister, Kristen M, Bourke, Lisa, Simmons, David, Roberts, Stuart K
Format: Article
Language:English
Subjects:
Adolescent
Age
Body Mass Index
Cross-Sectional Studies
Fatty liver
Female
Fibrosis
Healthy Lifestyle
Hepatitis
Humans
Liver diseases
Male
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - prevention & control
Obesity
Obesity - complications
Obesity - epidemiology
Original ‐ Hepatology (Clinical)
Prevalence
Risk Factors
Sex
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creator Vaz, Karl
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Majeed, Ammar
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Magliano, Dianna J
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Bourke, Lisa
Simmons, David
Roberts, Stuart K
description Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition globally. The aim of this study was to evaluate the change in age- and sex-standardized prevalence of NAFLD in regional Victoria over a 15-year period and explore the underlying factors associated with differences over time. Repeated comparative cross-sectional studies in four towns in regional Victoria, Australia. Individuals randomly selected from households from residential address lists from local government organizations in 2001-2003 (CrossRoads I [CR1]) and 2016-2018 (CrossRoads II [CR2]) with 1040 (99%) and 704 (94%) participants from CR1 and CR2 having complete data for analysis. Primary outcome was change in prevalence estimates of NAFLD (defined by a fatty liver index ≥ 60 in the absence of excess alcohol and viral hepatitis) between 2003 and 2018. Crude prevalence of NAFLD increased from 32.7% to 38.8% (P 
doi_str_mv 10.1111/jgh.16314
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The aim of this study was to evaluate the change in age- and sex-standardized prevalence of NAFLD in regional Victoria over a 15-year period and explore the underlying factors associated with differences over time. Repeated comparative cross-sectional studies in four towns in regional Victoria, Australia. Individuals randomly selected from households from residential address lists from local government organizations in 2001-2003 (CrossRoads I [CR1]) and 2016-2018 (CrossRoads II [CR2]) with 1040 (99%) and 704 (94%) participants from CR1 and CR2 having complete data for analysis. Primary outcome was change in prevalence estimates of NAFLD (defined by a fatty liver index ≥ 60 in the absence of excess alcohol and viral hepatitis) between 2003 and 2018. Crude prevalence of NAFLD increased from 32.7% to 38.8% (P &lt; 0.01), while age-standardized/sex-standardized prevalence increased from 32.4% to 35.4% (P &lt; 0.01). Concurrently, prevalence of obesity defined by BMI and elevated waist circumference increased 28% and 25%, respectively. Women had a greater increase in the prevalence of NAFLD than men, in parallel with increasing prevalence of obesity. Proportion of participants consuming takeaway food greater than once weekly increased significantly over time. Up to 60% of NAFLD patients require additional tests for assessment of significant fibrosis. 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ispartof Journal of gastroenterology and hepatology, 2023-10, Vol.38 (10), p.1823-1831
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source Wiley-Blackwell Read & Publish Collection
subjects Adolescent
Age
Body Mass Index
Cross-Sectional Studies
Fatty liver
Female
Fibrosis
Healthy Lifestyle
Hepatitis
Humans
Liver diseases
Male
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - prevention & control
Obesity
Obesity - complications
Obesity - epidemiology
Original ‐ Hepatology (Clinical)
Prevalence
Risk Factors
Sex
title Non-alcoholic fatty liver disease prevalence in Australia has risen over 15 years in conjunction with increased prevalence of obesity and reduction in healthy lifestyle
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