Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension

[Display omitted] •Using an animal model of PAH, SBRT can reduce pulmonary artery pressure by damaging the pulmonary sympathetic nerve.•SBRT is safe for non-target organs.•SBRT may be an alternative approach for catheter-based PADN. This study assesses the feasibility, safety, and effectiveness of n...

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Bibliographic Details
Published in:JACC. Basic to translational science 2024-02, Vol.9 (2), p.244-256
Main Authors: Xu, Wei, Wang, Ding-yu, Chen, Zi-yin, Gao, Qiang, Zou, Yi-lun, Sun, Dang-hui, Zhang, Song, Zhao, Xin-bo, Gong, Yong-tai, Zhang, Yun, Zhang, Da-xin, Li, Yue
Format: Article
Language:English
Subjects:
noninvasive stereotactic body radiotherapy
Original Research - Preclinical
pulmonary arterial hypertension
pulmonary artery
pulmonary artery denervation
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Summary:[Display omitted] •Using an animal model of PAH, SBRT can reduce pulmonary artery pressure by damaging the pulmonary sympathetic nerve.•SBRT is safe for non-target organs.•SBRT may be an alternative approach for catheter-based PADN. This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKnife group. Computed tomography, pulmonary angiography, and histology analysis revealed that SBRT was associated with minimal collateral damage.
ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2023.09.013