Hypernatremia and Its Rate of Correction: The Evidence So Far

Hypernatremia or high serum sodium levels can have many different causes, including insufficient free water intake, or excess free water losses. The management of hypernatremia focuses on resolving the underlying cause, replenishing free water deficit, and preventing further losses while closely mon...

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Published in:Curēus (Palo Alto, CA) CA), 2024-02, Vol.16 (2), p.e54699-e54699
Main Authors: Pokhriyal, Sindhu C, Joshi, Prachi, Gupta, Uma, Roy, Pulok, Parkash, Sunil, Kunwar, Kalendra, Al-Ghuraibawi, Muthanna Mohammed Hasan, Nagpal, Sagar, Yadav, Ruchi, Panigrahi, Kalpana
Format: Article
Language:English
Subjects:
COVID-19
Edema
Emergency Medicine
Head injuries
Hypernatremia
Internal Medicine
Keywords
Literature reviews
Medical Subject Headings-MeSH
Mortality
Nephrology
Observational studies
Patients
Severe acute respiratory syndrome coronavirus 2
Sodium
Subject heading schemes
Systematic review
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Summary:Hypernatremia or high serum sodium levels can have many different causes, including insufficient free water intake, or excess free water losses. The management of hypernatremia focuses on resolving the underlying cause, replenishing free water deficit, and preventing further losses while closely monitoring serum sodium concentration. This systematic review was carried out using medical databases such as PubMed, PubMed Central, and Google Scholar for relevant medical literature. The identified articles were reviewed, eligibility criteria were applied, and seven research articles were identified. The effect of the rate of hypernatremia correction on both short- and long-term outcomes in volume-resuscitated patients was the focus of our search for randomized or observational studies. Based on our analysis of the clinical evidence, we concluded that the present recommendations for treating acute and chronic hypernatremia in resuscitated patients do not stem from high-quality research.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.54699