Gray matter atrophy and white matter lesions burden in delayed cognitive decline following carbon monoxide poisoning

• Published in: Human brain mapping 2024-04, Vol.45 (5), p.e26656-e26656
• Main Authors: Zhang, Yanli, Wang, Tianhong, Wang, Shuaiwen, Zhuang, Xin, Li, Jianlin, Guo, Shunlin, Lei, Junqiang
• Format: Article
• Language: English
• Subjects: Atrophy; Carbon Monoxide Poisoning - complications; Carbon Monoxide Poisoning - diagnostic imaging; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - etiology; Disease Progression; Gray Matter - diagnostic imaging; Humans; White Matter - diagnostic imaging
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.26656

Gray matter (GM) atrophy and white matter (WM) lesions may contribute to cognitive decline in patients with delayed neurological sequelae (DNS) after carbon monoxide (CO) poisoning. However, there is currently a lack of evidence supporting this relationship. This study aimed to investigate the volume of GM, cortical thickness, and burden of WM lesions in 33 DNS patients with dementia, 24 DNS patients with mild cognitive impairment, and 51 healthy controls. Various methods, including voxel-based, deformation-based, surface-based, and atlas-based analyses, were used to examine GM structures. Furthermore, we explored the connection between GM volume changes, WM lesions burden, and cognitive decline. Compared to the healthy controls, both patient groups exhibited widespread GM atrophy in the cerebral cortices (for volume and cortical thickness), subcortical nuclei (for volume), and cerebellum (for volume) (p