Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sham-controlled trial

• Published in: Brain imaging and behavior 2024-02, Vol.18 (1), p.207-219
• Main Authors: Li, Xingbao, Caulfield, Kevin A., Hartwell, Karen. J., Henderson, Scott, Brady, Kathleen T., George, Mark S.
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Brain; Brain mapping; Cigarette smoking; Cigarettes; Cortex (cingulate); Double-Blind Method; Drug addiction; Executive function; Functional magnetic resonance imaging; Humans; Magnetic fields; Magnetic Resonance Imaging; Neural networks; Neuroimaging; Neuropsychology; Neuroradiology; Neurosciences; Prefrontal cortex; Prefrontal Cortex - physiology; Psychiatry; Reward; Smoking; Smoking cessation; Smoking Cessation - methods; Tobacco; Tobacco Use Disorder; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods
• ISSN: 1931-7565; 1931-7557; 1931-7565
• DOI: 10.1007/s11682-023-00820-3

Repetitive transcranial magnetic stimulation (rTMS) can reduce cue-elicited craving, decrease cigarette consumption, and increase the abstinence rate in tobacco use disorders (TUDs). We used functional magnetic resonance imaging (fMRI) to investigate the effect of 10 sessions of rTMS on cortical activity and neural networks in treatment-seeking smokers. Smoking cue exposure fMRI scans were acquired before and after the 10 sessions of active or sham rTMS (10 Hz, 3000 pulses per session) to the left dorsal lateral prefrontal cortex (DLPFC) in 42 treatment-seeking smokers (≥ 10 cigarettes per day). Brain activity and functional connectivity were compared before and after 10 sessions of rTMS. Ten sessions of rTMS significantly reduced the number of cigarettes consumed per day (62.93%) compared to sham treatment (39.43%) at the end of treatment (p = 0.027). fMRI results showed that the rTMS treatment increased brain activity in the dorsal anterior cingulate cortex (dACC) and DLPFC, but decreased brain activity in the bilateral medial orbitofrontal cortex (mOFC). The lower strength of dACC and mOFC connectivity was associated with quitting smoking (Wald score = 5.00, p = 0.025). The reduction of cigarette consumption significantly correlated with the increased brain activation in the dACC (r = 0.76, p = 0.0001). By increasing the brain activity in the dACC and prefrontal cortex and decreasing brain activity in the mOFC, 10 sessions of rTMS significantly reduced cigarette consumption and increased quit rate. Reduced drive-reward and executive control functional connectivity was associated with the smoking cessation effect from rTMS. Trial Registration ClinicalTrials.gov identifier: NCT02401672.