Low incidence of BRAF and NRAS mutations in a population with a high incidence of melanoma

Reported rates of BRAF mutation in Irish cutaneous melanoma cohorts are lower than the reported international data. We aimed to assess the mutational status of a cohort of primary cutaneous melanomas and to correlate it with clinical follow-up data. A total of 92 cases of primary cutaneous melanoma...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2024-03, Vol.484 (3), p.475-479
Main Authors: Neville, Grace, Marzario, Barbara, Shilling, David, Hand, Collette K, Heffron, Cynthia
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Melanoma
Mutation
Original
Original Article
Pathology
Statistical analysis
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Summary:Reported rates of BRAF mutation in Irish cutaneous melanoma cohorts are lower than the reported international data. We aimed to assess the mutational status of a cohort of primary cutaneous melanomas and to correlate it with clinical follow-up data. A total of 92 cases of primary cutaneous melanoma diagnosed at a single institution in 2012 were analyzed. Regions containing common mutations in the BRAF , NRAS , KIT , and KRAS genes were investigated by PCR amplification followed by Sanger sequencing. Demographic details, tumor characteristics, and 10-year outcome data were also obtained. Ten cases with BRAF V600E mutations (11.6%) and five (5.49%) NRAS mutations (4 at Q61R, 1 at Q61K) were detected. No statistically significant differences were noted between groups for age, gender, depth of invasion, nodal status, or recurrence status ( p ≥ 0.05). These findings suggest that the Irish population has a markedly lower incidence of BRAF and NRAS mutations in melanoma than those reported in other cohorts.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-023-03732-1