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Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens
Abstract Bile acids (BA), a series of hydroxylated steroids secreted by the liver, are involved in the digestion and absorption of dietary fats. In the present study, the effect of exogenous BAs on the performance and liver lipid metabolism of laying hens was investigated. Three hundred and sixty 50...
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| Published in: | Journal of animal science 2023-01, Vol.101 |
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| creator | Sun, Lijing Xin, Qian Jiao, Hongchao Wang, Xiaojuan Zhao, Jingpeng Li, Haifang Zhou, Yunlei Cao, Aizhi Wang, Jianmin Lin, Hai |
| description | Abstract
Bile acids (BA), a series of hydroxylated steroids secreted by the liver, are involved in the digestion and absorption of dietary fats. In the present study, the effect of exogenous BAs on the performance and liver lipid metabolism of laying hens was investigated. Three hundred and sixty 50-wk-old Hy-line Brown hens were randomly allocated into three groups and subjected to one of the following treatments: fed with the basal diet (control, Con), the basal diet supplemented with 0.1 g/kg (0.1 g/kg BAs), or 0.2 g/kg (0.2 g/kg BAs) porcine BAs. Laying performance, egg quality, and blood parameters were measured during the 8-wk experimental period. The expression of genes related to hepatic lipid metabolism was determined at the end of experiment. The results showed that BAs treatments had no influence (P > 0.05) on laying rate, egg weight, and feed efficiency. BAs treatment, however, significantly decreased mortality of hens (P = 0.006). BAs treatment showed a transient negative influence on eggshell quality at week 4 but not at week 8. The yolk color on week 8 was increased by BAs treatments (P |
| doi_str_mv | 10.1093/jas/skad334 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11025372</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jas/skad334</oup_id><sourcerecordid>3041052828</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3556-e3798cf416f21b923d849ac9f3da47d81df49b41e1c9656fb60ab64d87ff8a003</originalsourceid><addsrcrecordid>eNp9kUuLFDEURoMoTju6ci8BQQRpJ49KVbIaZBgfMOBG1yGV3HSnTSVlUiXOvzdDt4O6EC5kcQ-H--VD6DklbylR_OJg6kX9Zhzn3QO0oYKJLac9f4g2hDC6lZKyM_Sk1gMhlAklHqMzPgwD76jYoHLtPdgFZ4_hZ95BymvFY4iAq4lLxXWd5wgTpMUsISfcZtkDnqH4XCaTLGCTHN7D3PYWxzAHhydYzJhjqNOd1-zA4WhuQ9o1LtWn6JE3scKz03uOvr6__nL1cXvz-cOnq3c3W8uF6LfAByWt72jvGR0V4052yljluTPd4CR1vlNjR4Fa1Yvejz0xY985OXgvDSH8HF0evfM6TuBsy1BM1HMJkym3Opug_96ksNe7_ENTSpjgA2uG1ydDyd9XqIueQrUQo0nQ_kkzORClBBv6hr78Bz3ktaSWT3PSUSKYZLJRb46ULbnWAv7-Gkr0XZm6lalPZTb6xZ8B7tnf7TXg1RHI6_xf0y_ugKrk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3041052828</pqid></control><display><type>article</type><title>Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens</title><source>Oxford Journals Online</source><source>PubMed Central</source><creator>Sun, Lijing ; Xin, Qian ; Jiao, Hongchao ; Wang, Xiaojuan ; Zhao, Jingpeng ; Li, Haifang ; Zhou, Yunlei ; Cao, Aizhi ; Wang, Jianmin ; Lin, Hai</creator><creatorcontrib>Sun, Lijing ; Xin, Qian ; Jiao, Hongchao ; Wang, Xiaojuan ; Zhao, Jingpeng ; Li, Haifang ; Zhou, Yunlei ; Cao, Aizhi ; Wang, Jianmin ; Lin, Hai</creatorcontrib><description>Abstract
Bile acids (BA), a series of hydroxylated steroids secreted by the liver, are involved in the digestion and absorption of dietary fats. In the present study, the effect of exogenous BAs on the performance and liver lipid metabolism of laying hens was investigated. Three hundred and sixty 50-wk-old Hy-line Brown hens were randomly allocated into three groups and subjected to one of the following treatments: fed with the basal diet (control, Con), the basal diet supplemented with 0.1 g/kg (0.1 g/kg BAs), or 0.2 g/kg (0.2 g/kg BAs) porcine BAs. Laying performance, egg quality, and blood parameters were measured during the 8-wk experimental period. The expression of genes related to hepatic lipid metabolism was determined at the end of experiment. The results showed that BAs treatments had no influence (P > 0.05) on laying rate, egg weight, and feed efficiency. BAs treatment, however, significantly decreased mortality of hens (P = 0.006). BAs treatment showed a transient negative influence on eggshell quality at week 4 but not at week 8. The yolk color on week 8 was increased by BAs treatments (P < 0.0001) compared to control. The duodenum index showed a tendency to be increased (P = 0.053) and jejunum index were increased (P = 0.007) by BAs treatment. Compared to control, BAs treatments decreased lipid droplet content (P < 0.0001) and TG content (P = 0.002) of liver. Fatty acid synthase activity was also decreased as an effect of BAs dietary supplementation. Compared to the control group, 0.1 g/kg BAs treatment increased (P < 0.05) the mRNA expression of genes Farnesoid X receptor (FXR) (P = 0.042), cytochrome P450 family 7 subfamily A member 1 (CYP7A1) (P = 0.002), and cytochrome P450 family 8 subfamily B member 1 (CYP8B1) (P = 0.017), fatty acid synthase (FAS) (P = 0.020), acetyl-CoA carboxylase (ACC) (P = 0.032), sterol regulatory element binding protein-1c (SREBP-1c) (P = 0.037), proliferator-activated receptor gamma (PPARγ) (P = 0.002), apolipoprotein B (APO-B) (P = 0.020), and very low density lipoprotein receptor (VLDLR) (P = 0.024). In conclusion, the addition of exogenous BAs reduces lipid accumulation in liver. BA supplementation reduces the mortality of hens and improves egg yolk color, with no unfavorable effect on laying performance. The result suggests that suppressed FAS activity is involved in the reduced hepatic lipid accumulation by BAs treatment.
Bile acids suppress lipid accumulation in the liver of laying hens. Bile acids supplementation reduce the mortality of hens and improve egg yolk color.
Lay Summary
Fatty liver hemorrhagic syndrome is one of the most common diseases in laying hens and is a metabolic disease characterized by disorders of lipid metabolism in the liver, manifested by fatty liver degeneration and varying degrees of hemorrhage, which often occurs in caged hens in good condition and with high egg production rates. Bile acids (BA), a group of hydroxylated steroids synthesized from cholesterol in the liver, play an important role in lipid metabolism. This study aimed to examine the effects of dietary addition of different levels of BAs on the production performance and liver fat metabolism of 50-wk-old Hy-line Brown hens. The result indicates that the addition of exogenous BAs reduces lipid accumulation in liver. BAs supplementation reduces the mortality of hens and improves egg yolk color, with no other unfavorable side effects on laying performance. The results of the present study suggest that suppressed fatty acid synthase activity is involved in the reduced hepatic lipid accumulation as an effect of BAs dietary supplementation.</description><identifier>ISSN: 0021-8812</identifier><identifier>ISSN: 1525-3163</identifier><identifier>EISSN: 1525-3163</identifier><identifier>DOI: 10.1093/jas/skad334</identifier><identifier>PMID: 37773415</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Accumulation ; Acetyl-CoA carboxylase ; Animal Feed - analysis ; Animals ; Apolipoprotein B ; Bile acids ; Bile Acids and Salts - metabolism ; Chickens - metabolism ; Color ; Cytochrome ; Cytochrome P450 ; Cytochromes P450 ; Diet ; Diet - veterinary ; Dietary Fats - pharmacology ; Dietary Supplements ; Duodenum ; Egg shells ; Eggs ; Fatty Acid Synthases ; Fatty acids ; Fatty-acid synthase ; Feed conversion ; Feed efficiency ; Feeds ; Female ; Gene expression ; Genes ; Jejunum ; Lipid Metabolism ; Lipids ; Liver ; Liver - metabolism ; Low density lipoprotein ; Low density lipoprotein receptors ; Metabolism ; Mortality ; Ovum - metabolism ; Poultry ; Receptor density ; Receptors ; Steroid hormones ; Sterol regulatory element-binding protein ; Swine ; Yolk</subject><ispartof>Journal of animal science, 2023-01, Vol.101</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3556-e3798cf416f21b923d849ac9f3da47d81df49b41e1c9656fb60ab64d87ff8a003</citedby><cites>FETCH-LOGICAL-c3556-e3798cf416f21b923d849ac9f3da47d81df49b41e1c9656fb60ab64d87ff8a003</cites><orcidid>0000-0002-0878-137X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11025372/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11025372/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37773415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Lijing</creatorcontrib><creatorcontrib>Xin, Qian</creatorcontrib><creatorcontrib>Jiao, Hongchao</creatorcontrib><creatorcontrib>Wang, Xiaojuan</creatorcontrib><creatorcontrib>Zhao, Jingpeng</creatorcontrib><creatorcontrib>Li, Haifang</creatorcontrib><creatorcontrib>Zhou, Yunlei</creatorcontrib><creatorcontrib>Cao, Aizhi</creatorcontrib><creatorcontrib>Wang, Jianmin</creatorcontrib><creatorcontrib>Lin, Hai</creatorcontrib><title>Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description>Abstract
Bile acids (BA), a series of hydroxylated steroids secreted by the liver, are involved in the digestion and absorption of dietary fats. In the present study, the effect of exogenous BAs on the performance and liver lipid metabolism of laying hens was investigated. Three hundred and sixty 50-wk-old Hy-line Brown hens were randomly allocated into three groups and subjected to one of the following treatments: fed with the basal diet (control, Con), the basal diet supplemented with 0.1 g/kg (0.1 g/kg BAs), or 0.2 g/kg (0.2 g/kg BAs) porcine BAs. Laying performance, egg quality, and blood parameters were measured during the 8-wk experimental period. The expression of genes related to hepatic lipid metabolism was determined at the end of experiment. The results showed that BAs treatments had no influence (P > 0.05) on laying rate, egg weight, and feed efficiency. BAs treatment, however, significantly decreased mortality of hens (P = 0.006). BAs treatment showed a transient negative influence on eggshell quality at week 4 but not at week 8. The yolk color on week 8 was increased by BAs treatments (P < 0.0001) compared to control. The duodenum index showed a tendency to be increased (P = 0.053) and jejunum index were increased (P = 0.007) by BAs treatment. Compared to control, BAs treatments decreased lipid droplet content (P < 0.0001) and TG content (P = 0.002) of liver. Fatty acid synthase activity was also decreased as an effect of BAs dietary supplementation. Compared to the control group, 0.1 g/kg BAs treatment increased (P < 0.05) the mRNA expression of genes Farnesoid X receptor (FXR) (P = 0.042), cytochrome P450 family 7 subfamily A member 1 (CYP7A1) (P = 0.002), and cytochrome P450 family 8 subfamily B member 1 (CYP8B1) (P = 0.017), fatty acid synthase (FAS) (P = 0.020), acetyl-CoA carboxylase (ACC) (P = 0.032), sterol regulatory element binding protein-1c (SREBP-1c) (P = 0.037), proliferator-activated receptor gamma (PPARγ) (P = 0.002), apolipoprotein B (APO-B) (P = 0.020), and very low density lipoprotein receptor (VLDLR) (P = 0.024). In conclusion, the addition of exogenous BAs reduces lipid accumulation in liver. BA supplementation reduces the mortality of hens and improves egg yolk color, with no unfavorable effect on laying performance. The result suggests that suppressed FAS activity is involved in the reduced hepatic lipid accumulation by BAs treatment.
Bile acids suppress lipid accumulation in the liver of laying hens. Bile acids supplementation reduce the mortality of hens and improve egg yolk color.
Lay Summary
Fatty liver hemorrhagic syndrome is one of the most common diseases in laying hens and is a metabolic disease characterized by disorders of lipid metabolism in the liver, manifested by fatty liver degeneration and varying degrees of hemorrhage, which often occurs in caged hens in good condition and with high egg production rates. Bile acids (BA), a group of hydroxylated steroids synthesized from cholesterol in the liver, play an important role in lipid metabolism. This study aimed to examine the effects of dietary addition of different levels of BAs on the production performance and liver fat metabolism of 50-wk-old Hy-line Brown hens. The result indicates that the addition of exogenous BAs reduces lipid accumulation in liver. BAs supplementation reduces the mortality of hens and improves egg yolk color, with no other unfavorable side effects on laying performance. The results of the present study suggest that suppressed fatty acid synthase activity is involved in the reduced hepatic lipid accumulation as an effect of BAs dietary supplementation.</description><subject>Accumulation</subject><subject>Acetyl-CoA carboxylase</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Apolipoprotein B</subject><subject>Bile acids</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Chickens - metabolism</subject><subject>Color</subject><subject>Cytochrome</subject><subject>Cytochrome P450</subject><subject>Cytochromes P450</subject><subject>Diet</subject><subject>Diet - veterinary</subject><subject>Dietary Fats - pharmacology</subject><subject>Dietary Supplements</subject><subject>Duodenum</subject><subject>Egg shells</subject><subject>Eggs</subject><subject>Fatty Acid Synthases</subject><subject>Fatty acids</subject><subject>Fatty-acid synthase</subject><subject>Feed conversion</subject><subject>Feed efficiency</subject><subject>Feeds</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Jejunum</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Low density lipoprotein</subject><subject>Low density lipoprotein receptors</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Ovum - metabolism</subject><subject>Poultry</subject><subject>Receptor density</subject><subject>Receptors</subject><subject>Steroid hormones</subject><subject>Sterol regulatory element-binding protein</subject><subject>Swine</subject><subject>Yolk</subject><issn>0021-8812</issn><issn>1525-3163</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kUuLFDEURoMoTju6ci8BQQRpJ49KVbIaZBgfMOBG1yGV3HSnTSVlUiXOvzdDt4O6EC5kcQ-H--VD6DklbylR_OJg6kX9Zhzn3QO0oYKJLac9f4g2hDC6lZKyM_Sk1gMhlAklHqMzPgwD76jYoHLtPdgFZ4_hZ95BymvFY4iAq4lLxXWd5wgTpMUsISfcZtkDnqH4XCaTLGCTHN7D3PYWxzAHhydYzJhjqNOd1-zA4WhuQ9o1LtWn6JE3scKz03uOvr6__nL1cXvz-cOnq3c3W8uF6LfAByWt72jvGR0V4052yljluTPd4CR1vlNjR4Fa1Yvejz0xY985OXgvDSH8HF0evfM6TuBsy1BM1HMJkym3Opug_96ksNe7_ENTSpjgA2uG1ydDyd9XqIueQrUQo0nQ_kkzORClBBv6hr78Bz3ktaSWT3PSUSKYZLJRb46ULbnWAv7-Gkr0XZm6lalPZTb6xZ8B7tnf7TXg1RHI6_xf0y_ugKrk</recordid><startdate>20230103</startdate><enddate>20230103</enddate><creator>Sun, Lijing</creator><creator>Xin, Qian</creator><creator>Jiao, Hongchao</creator><creator>Wang, Xiaojuan</creator><creator>Zhao, Jingpeng</creator><creator>Li, Haifang</creator><creator>Zhou, Yunlei</creator><creator>Cao, Aizhi</creator><creator>Wang, Jianmin</creator><creator>Lin, Hai</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0878-137X</orcidid></search><sort><creationdate>20230103</creationdate><title>Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens</title><author>Sun, Lijing ; Xin, Qian ; Jiao, Hongchao ; Wang, Xiaojuan ; Zhao, Jingpeng ; Li, Haifang ; Zhou, Yunlei ; Cao, Aizhi ; Wang, Jianmin ; Lin, Hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3556-e3798cf416f21b923d849ac9f3da47d81df49b41e1c9656fb60ab64d87ff8a003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Accumulation</topic><topic>Acetyl-CoA carboxylase</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Apolipoprotein B</topic><topic>Bile acids</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Chickens - metabolism</topic><topic>Color</topic><topic>Cytochrome</topic><topic>Cytochrome P450</topic><topic>Cytochromes P450</topic><topic>Diet</topic><topic>Diet - veterinary</topic><topic>Dietary Fats - pharmacology</topic><topic>Dietary Supplements</topic><topic>Duodenum</topic><topic>Egg shells</topic><topic>Eggs</topic><topic>Fatty Acid Synthases</topic><topic>Fatty acids</topic><topic>Fatty-acid synthase</topic><topic>Feed conversion</topic><topic>Feed efficiency</topic><topic>Feeds</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Jejunum</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Low density lipoprotein</topic><topic>Low density lipoprotein receptors</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Ovum - metabolism</topic><topic>Poultry</topic><topic>Receptor density</topic><topic>Receptors</topic><topic>Steroid hormones</topic><topic>Sterol regulatory element-binding protein</topic><topic>Swine</topic><topic>Yolk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Lijing</creatorcontrib><creatorcontrib>Xin, Qian</creatorcontrib><creatorcontrib>Jiao, Hongchao</creatorcontrib><creatorcontrib>Wang, Xiaojuan</creatorcontrib><creatorcontrib>Zhao, Jingpeng</creatorcontrib><creatorcontrib>Li, Haifang</creatorcontrib><creatorcontrib>Zhou, Yunlei</creatorcontrib><creatorcontrib>Cao, Aizhi</creatorcontrib><creatorcontrib>Wang, Jianmin</creatorcontrib><creatorcontrib>Lin, Hai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Lijing</au><au>Xin, Qian</au><au>Jiao, Hongchao</au><au>Wang, Xiaojuan</au><au>Zhao, Jingpeng</au><au>Li, Haifang</au><au>Zhou, Yunlei</au><au>Cao, Aizhi</au><au>Wang, Jianmin</au><au>Lin, Hai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>2023-01-03</date><risdate>2023</risdate><volume>101</volume><issn>0021-8812</issn><issn>1525-3163</issn><eissn>1525-3163</eissn><abstract>Abstract
Bile acids (BA), a series of hydroxylated steroids secreted by the liver, are involved in the digestion and absorption of dietary fats. In the present study, the effect of exogenous BAs on the performance and liver lipid metabolism of laying hens was investigated. Three hundred and sixty 50-wk-old Hy-line Brown hens were randomly allocated into three groups and subjected to one of the following treatments: fed with the basal diet (control, Con), the basal diet supplemented with 0.1 g/kg (0.1 g/kg BAs), or 0.2 g/kg (0.2 g/kg BAs) porcine BAs. Laying performance, egg quality, and blood parameters were measured during the 8-wk experimental period. The expression of genes related to hepatic lipid metabolism was determined at the end of experiment. The results showed that BAs treatments had no influence (P > 0.05) on laying rate, egg weight, and feed efficiency. BAs treatment, however, significantly decreased mortality of hens (P = 0.006). BAs treatment showed a transient negative influence on eggshell quality at week 4 but not at week 8. The yolk color on week 8 was increased by BAs treatments (P < 0.0001) compared to control. The duodenum index showed a tendency to be increased (P = 0.053) and jejunum index were increased (P = 0.007) by BAs treatment. Compared to control, BAs treatments decreased lipid droplet content (P < 0.0001) and TG content (P = 0.002) of liver. Fatty acid synthase activity was also decreased as an effect of BAs dietary supplementation. Compared to the control group, 0.1 g/kg BAs treatment increased (P < 0.05) the mRNA expression of genes Farnesoid X receptor (FXR) (P = 0.042), cytochrome P450 family 7 subfamily A member 1 (CYP7A1) (P = 0.002), and cytochrome P450 family 8 subfamily B member 1 (CYP8B1) (P = 0.017), fatty acid synthase (FAS) (P = 0.020), acetyl-CoA carboxylase (ACC) (P = 0.032), sterol regulatory element binding protein-1c (SREBP-1c) (P = 0.037), proliferator-activated receptor gamma (PPARγ) (P = 0.002), apolipoprotein B (APO-B) (P = 0.020), and very low density lipoprotein receptor (VLDLR) (P = 0.024). In conclusion, the addition of exogenous BAs reduces lipid accumulation in liver. BA supplementation reduces the mortality of hens and improves egg yolk color, with no unfavorable effect on laying performance. The result suggests that suppressed FAS activity is involved in the reduced hepatic lipid accumulation by BAs treatment.
Bile acids suppress lipid accumulation in the liver of laying hens. Bile acids supplementation reduce the mortality of hens and improve egg yolk color.
Lay Summary
Fatty liver hemorrhagic syndrome is one of the most common diseases in laying hens and is a metabolic disease characterized by disorders of lipid metabolism in the liver, manifested by fatty liver degeneration and varying degrees of hemorrhage, which often occurs in caged hens in good condition and with high egg production rates. Bile acids (BA), a group of hydroxylated steroids synthesized from cholesterol in the liver, play an important role in lipid metabolism. This study aimed to examine the effects of dietary addition of different levels of BAs on the production performance and liver fat metabolism of 50-wk-old Hy-line Brown hens. The result indicates that the addition of exogenous BAs reduces lipid accumulation in liver. BAs supplementation reduces the mortality of hens and improves egg yolk color, with no other unfavorable side effects on laying performance. The results of the present study suggest that suppressed fatty acid synthase activity is involved in the reduced hepatic lipid accumulation as an effect of BAs dietary supplementation.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>37773415</pmid><doi>10.1093/jas/skad334</doi><orcidid>https://orcid.org/0000-0002-0878-137X</orcidid></addata></record> |
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| source | Oxford Journals Online; PubMed Central |
| subjects | Accumulation Acetyl-CoA carboxylase Animal Feed - analysis Animals Apolipoprotein B Bile acids Bile Acids and Salts - metabolism Chickens - metabolism Color Cytochrome Cytochrome P450 Cytochromes P450 Diet Diet - veterinary Dietary Fats - pharmacology Dietary Supplements Duodenum Egg shells Eggs Fatty Acid Synthases Fatty acids Fatty-acid synthase Feed conversion Feed efficiency Feeds Female Gene expression Genes Jejunum Lipid Metabolism Lipids Liver Liver - metabolism Low density lipoprotein Low density lipoprotein receptors Metabolism Mortality Ovum - metabolism Poultry Receptor density Receptors Steroid hormones Sterol regulatory element-binding protein Swine Yolk |
| title | Effect of exogenous bile salts supplementation on the performance and hepatic lipid metabolism of aged laying hens |
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