Prognostic Factors for Japanese Adults With Acute Community-Acquired Bacterial Meningitis: A Retrospective Study

Background This study aimed to determine if the cerebrospinal fluid (CSF) cell count is useful for predicting the infection severity or prognosis in Japanese adults with community-acquired bacterial meningitis. Methodology This study retrospectively evaluated the prognosis of patients diagnosed with...

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Published in:Curēus (Palo Alto, CA) CA), 2024-04, Vol.16 (4), p.e57642-e57642
Main Authors: Matsuki, Yoshiyuki, Oda, Toshimi, Fukao, Eri, Sugiura, Ayaka, Yokozawa, Takayuki, Honma, Yutaka
Format: Article
Language:English
Subjects:
Antibiotics
Bacterial infections
Blood tests
Cerebrospinal fluid
Consciousness
Contamination
Diabetes
Glasgow Coma Scale
Glucose
Hematology
Hospitalization
Infectious Disease
Internal Medicine
Magnetic resonance imaging
Medical prognosis
Medical records
Meningitis
Mortality
Neurology
Patients
Proteins
Regression analysis
Staphylococcus infections
Streptococcus infections
Stroke
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Summary:Background This study aimed to determine if the cerebrospinal fluid (CSF) cell count is useful for predicting the infection severity or prognosis in Japanese adults with community-acquired bacterial meningitis. Methodology This study retrospectively evaluated the prognosis of patients diagnosed with community-acquired bacterial meningitis at our hospital from January 2004 to December 2021 using the modified Rankin scale (mRs) (Showa General Hospital; N = 39). Patients were classified into the following two groups: (i) favorable (mRs: 0-3) and (ii) unfavorable (mRs: 4-6). Eight factors were selected and compared with outcomes, and then two factors were evaluated from those, and a multivariate logistic regression was used to determine the significant variables. Results CSF cell count was observed to be associated with poor prognoses (odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.99995-0.99999, p = 0.0012). Glasgow coma scale (GCS) score on admission was also observed to be associated with poor prognoses (OR = 0.93, 95% CI = 0.89145-0.97290, p = 0.0029). Conclusions Low CSF cell count and low GCS on admission were observed as risk factors for poor prognoses in patients with bacterial meningitis.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.57642