Baseline characteristics of eyes with early residual fluid post loading phase of aflibercept therapy in neovascular AMD: PRECISE study report 3

• Published in: Eye (London) 2024-05, Vol.38 (7), p.1301-1307
• Main Authors: Chandra, Shruti, Gurudas, Sarega, Pearce, Ian, Mckibbin, Martin, Kotagiri, Ajay, Menon, Geeta, Burton, Benjamin J. L., Talks, James, Grabowska, Anna, Ghanchi, Faruque, Gale, Richard, Giani, Andrea, Chong, Victor, Chen, Ching Ning Taffeta, Nicholson, Luke, Thottarath, Sridevi, Chandak, Swati, Sivaprasad, Sobha
• Format: Article
• Language: English
• Subjects: 692/53/2423; 706/703; Aged; Aged, 80 and over; Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - therapeutic use; Clinical medicine; Clinical trials; Demography; Female; Humans; Intravitreal Injections; Laboratory Medicine; Macular degeneration; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Patients; Pharmaceutical Sciences/Technology; Receptors, Vascular Endothelial Growth Factor - administration & dosage; Receptors, Vascular Endothelial Growth Factor - therapeutic use; Recombinant Fusion Proteins - administration & dosage; Recombinant Fusion Proteins - therapeutic use; ROC Curve; Subretinal Fluid; Surgery; Surgical Oncology; Teaching hospitals; Tomography, Optical Coherence; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Visual acuity; Visual Acuity - physiology; Wet Macular Degeneration - diagnosis; Wet Macular Degeneration - drug therapy; Wet Macular Degeneration - physiopathology
• ISSN: 0950-222X; 1476-5454; 1476-5454
• DOI: 10.1038/s41433-023-02886-1

Purpose To compare the baseline characteristics in patients with and without early residual fluid (ERF) after aflibercept loading phase (LP) in patients with treatment naïve neovascular age related macular degeneration (nAMD). Methods Patients with nAMD initiated on LP of three intravitreal aflibercept doses were recruited from December 2019 to August 2021. Baseline demographic and OCT features associated with any ERF were analysed using Generalised Estimating Equations to account for inter-eye correlation. Receiver operating characteristic (ROC) curve was performed for selection of CST threshold. Results Of 2128 patients enrolled, 1999 eyes of 1862 patients with complete data were included. After LP, ERF was present in 1000 (50.0%), eSRF in 746(37.3%) and eIRF in 428 (21.4%) eyes. In multivariable analysis of baseline features, eyes with increased central subfield thickness (CST) (OR 1.31 per 100 microns increase [95% CI 1.22 to 1.41]; P