N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation

The ubiquitin-binding endoribonuclease N4BP1 potently suppresses cytokine production by Toll-like receptors (TLRs) that signal through the adaptor MyD88 but is inactivated via caspase-8-mediated cleavage downstream of death receptors, TLR3, or TLR4. Here, we examined the mechanism whereby N4BP1 limi...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Mass.), 2024-05, Vol.57 (5), p.973-986.e7
Main Authors:	Gitlin, Alexander D., Maltzman, Allie, Kanno, Yuzuka, Heger, Klaus, Reja, Rohit, Schubert, Alexander F., Wierciszewski, Linsey J., Pantua, Homer, Kapadia, Sharookh B., Harris, Seth F., Webster, Joshua D., Newton, Kim, Dixit, Vishva M.
Format:	Article
Language:	English
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals cytokines Cytokines - metabolism Endoribonucleases - genetics Endoribonucleases - metabolism I-kappa B Kinase - genetics I-kappa B Kinase - metabolism inflammation Inflammation - immunology Inflammation - metabolism innate immunity Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction Toll-like receptors Toll-Like Receptors - metabolism Ubiquitin - metabolism
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