role of endosomal-recycling in long-term potentiation

Long-term potentiation (LTP) defines persistent increases in neurotransmission strength at synapses that are triggered by specific patterns of neuronal activity. LTP, the most widely accepted molecular model for learning, is best characterised at glutamatergic synapses on dendritic spines. In this c...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2011-01, Vol.68 (2), p.185-194
Main Authors: Kelly, Eoin E, Horgan, Conor P, McCaffrey, Mary W, Young, Paul
Format: Article
Language:English
Subjects:
AMPAR
Biochemistry
Biological Transport
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Compartmentation
Cellular biology
Dendrites - physiology
Dendrites - ultrastructure
Dendritic Spines - metabolism
Endosomal-recycling
Endosomes - metabolism
FIP2
Hippocampus - physiology
Humans
Life Sciences
Long-Term Potentiation - physiology
LTP
Membranes
Memory - physiology
Myosin V
Neurons
Neurons - physiology
Neurons - ultrastructure
Neurotransmitters
NMDAR
Proteins
Receptors, Glutamate - metabolism
Recycling
Review
Spine
Synapses - metabolism
Synaptic Transmission
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Summary:Long-term potentiation (LTP) defines persistent increases in neurotransmission strength at synapses that are triggered by specific patterns of neuronal activity. LTP, the most widely accepted molecular model for learning, is best characterised at glutamatergic synapses on dendritic spines. In this context, LTP involves increases in dendritic spine size and the insertion of glutamate receptors into the post-synaptic spine membrane, which together boost post-synaptic responsiveness to neurotransmitters. In dendrites, the material required for LTP is sourced from an organelle termed the endosomal-recycling compartment (ERC), which is localised to the base of dendritic spines. When LTP is induced, material derived from the recycling compartment, which contains α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-type glutamate receptors (AMPARs), is mobilised into dendritic spines feeding the increased need for receptors and membrane at the spine neck and head. In this review, we discuss the importance of endosomal-recycling and the role of key proteins which control these processes in the context of LTP.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-010-0516-2