Clinical Outcomes in a Randomized Controlled Trial Comparing Point-of-Care With Standard Human Immunodeficiency Virus (HIV) Viral Load Monitoring in Nigeria

Abstract Background Point-of-care (POC) viral load (VL) tests provide results within hours, enabling same-day treatment interventions. We assessed treatment outcomes with POC vs standard-of-care (SOC) VL monitoring. Methods We implemented a randomized controlled trial at an urban and rural hospital...

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Bibliographic Details
Published in:Clinical infectious diseases 2023-02, Vol.76 (3), p.e681-e691
Main Authors: Chang, Charlotte, Agbaji, Oche, Mitruka, Kiren, Olatunde, Bola, Sule, Halima, Dajel, Titus, Zee, Aaron, Ahmed, Mukhtar L, Ahmed, Isah, Okonkwo, Prosper, Chaplin, Beth, Kanki, Phyllis
Format: Article
Language:English
Subjects:
Anti-HIV Agents - therapeutic use
HIV
HIV Infections - drug therapy
Humans
Nigeria
Point-of-Care Systems
Viral Load - methods
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Summary:Abstract Background Point-of-care (POC) viral load (VL) tests provide results within hours, enabling same-day treatment interventions. We assessed treatment outcomes with POC vs standard-of-care (SOC) VL monitoring. Methods We implemented a randomized controlled trial at an urban and rural hospital in Nigeria. Participants initiating antiretroviral therapy (ART) were randomized 1:1 for monitoring via the POC Cepheid Xpert or SOC Roche COBAS (v2.0) HIV-1 VL assays. Viral suppression (VS) and retention in care at 12 months were compared via intention-to-treat (ITT) and per-protocol (PP) analyses. Post-trial surveys for POC patients and healthcare workers (HCWs) evaluated acceptability. Results During April 2018–October 2019, 268 SOC and 273 POC patients enrolled in the trial. Viral suppression at
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac605