Optical-coherence-tomography-based deep-learning scatterer-density estimator using physically accurate noise model

We demonstrate a deep-learning-based scatterer density estimator (SDE) that processes local speckle patterns of optical coherence tomography (OCT) images and estimates the scatterer density behind each speckle pattern. The SDE is trained using large quantities of numerically simulated OCT images and...

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Bibliographic Details
Published in:Biomedical optics express 2024-05, Vol.15 (5), p.2832-2848
Main Authors: Seesan, Thitiya, Mukherjee, Pradipta, Abd El-Sadek, Ibrahim, Lim, Yiheng, Zhu, Lida, Makita, Shuichi, Yasuno, Yoshiaki
Format: Article
Language:English
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Summary:We demonstrate a deep-learning-based scatterer density estimator (SDE) that processes local speckle patterns of optical coherence tomography (OCT) images and estimates the scatterer density behind each speckle pattern. The SDE is trained using large quantities of numerically simulated OCT images and their associated scatterer densities. The numerical simulation uses a noise model that incorporates the spatial properties of three types of noise, i.e., shot noise, relative-intensity noise, and non-optical noise. The SDE's performance was evaluated numerically and experimentally using two types of scattering phantom and tumor spheroids. The results confirmed that the SDE estimates scatterer densities accurately. The estimation accuracy improved significantly when compared with our previous deep-learning-based SDE, which was trained using numerical speckle patterns generated from a noise model that did not account for the spatial properties of noise.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.519743