Plasma proteomic signature of human longevity

The identification of protein targets that exhibit anti‐aging clinical potential could inform interventions to lengthen the human health span. Most previous proteomics research has been focused on chronological age instead of longevity. We leveraged two large population‐based prospective cohorts wit...

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Bibliographic Details
Published in:Aging cell 2024-06, Vol.23 (6), p.e14136-n/a
Main Authors: Liu, Xiaojuan, Axelsson, Gisli Thor, Newman, Anne B., Psaty, Bruce M., Boudreau, Robert M., Wu, Chenkai, Arnold, Alice M., Aspelund, Thor, Austin, Thomas R., Gardin, Julius M., Siggeirsdottir, Kristin, Tracy, Russell P., Gerszten, Robert E., Launer, Lenore J., Jennings, Lori L., Gudnason, Vilmundur, Sanders, Jason L., Odden, Michelle C.
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Aging
Aging - blood
Biomarkers
Biomarkers - blood
Blood pressure
Cholesterol
Cognitive ability
Cohort Studies
Female
Glucose
Humans
Hypotheses
Longevity
Longevity - physiology
Main Issue
Male
Middle Aged
Mortality
Plasma
Prediction models
Proteins
Proteomics
Proteomics - methods
Replication
Smoking
Sociodemographics
Therapeutic targets
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Summary:The identification of protein targets that exhibit anti‐aging clinical potential could inform interventions to lengthen the human health span. Most previous proteomics research has been focused on chronological age instead of longevity. We leveraged two large population‐based prospective cohorts with long follow‐ups to evaluate the proteomic signature of longevity defined by survival to 90 years of age. Plasma proteomics was measured using a SOMAscan assay in 3067 participants from the Cardiovascular Health Study (discovery cohort) and 4690 participants from the Age Gene/Environment Susceptibility‐Reykjavik Study (replication cohort). Logistic regression identified 211 significant proteins in the CHS cohort using a Bonferroni‐adjusted threshold, of which 168 were available in the replication cohort and 105 were replicated (corrected p value
ISSN:1474-9718
1474-9726
1474-9726
DOI:10.1111/acel.14136