Stratification by obesity class, rather than age, can identify a higher percent of children at risk for non‐alcoholic fatty liver disease and metabolic dysfunction

• Published in: Pediatric obesity 2022-03, Vol.17 (3), p.e12862-n/a
• Main Authors: Radulescu, Aurelia, Dugan, Adam J., Killian, Mary, Attia, Suzanna L., Mouzaki, Marialena, Fuchs, George J., Kohli, Rohit, Bada, Henrietta, Kern, Philip A., Softic, Samir
• Format: Article
• Language: English
• Subjects: Age groups; Alanine Transaminase; ALT; Child; Childrens health; Cross-Sectional Studies; diabetes; dyslipidaemia; Female; Hispanic or Latino; Humans; Liver diseases; Male; Metabolic disorders; Metabolism; NAFLD; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - epidemiology; Obesity; paediatric; Pediatric Obesity - classification; Pediatric Obesity - epidemiology; Pediatrics
• ISSN: 2047-6302; 2047-6310; 2047-6310
• DOI: 10.1111/ijpo.12862

Summary Background An increasing number of clinical practice guidelines recommend screening children with obesity for non‐alcoholic fatty liver disease (NAFLD). However, there is limited evidence regarding what parameters should be used to initiate the screening. Objective The objective of this study was to determine whether obesity class rather than age group can identify a higher percent of children at risk of NAFLD as assessed by abnormal alanine aminotransferase (ALT). Methods This is a cross‐sectional study in a regional referral clinic for evaluation of obesity. Children were stratified by age group or by obesity class, and data obtained at first visit were analysed. Results Of the 784 children, 482 were ≥10, 209 were 6 to 9 and 93 were 2 to 5 years of age. Abnormal ALT was observed in 32.1%, 46.9% and 61.0% of children with class I, II or III obesity, respectively (p