Therapy-Associated Polyposis, Late Presentation of a Childhood-Treated Disease

Therapy-associated polyposis (TAP), an acquired gastrointestinal polyposis in childhood cancer survivors, poses diagnostic challenges resembling hereditary syndromes. Four TAP patients were studied, revealing upper gastrointestinal lesions after radiotherapy in 2 patients, managed by endoscopic rese...

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Bibliographic Details
Published in:ACG case reports journal 2024-06, Vol.11 (6), p.e01379-e01379
Main Authors: McGarrity, Thomas J, Aynardi, Jason, Peiffer, Laurie, Ashktorab, Hassan, Razjouyan, Hadie
Format: Article
Language:English
Subjects:
Case Report
Colon
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Summary:Therapy-associated polyposis (TAP), an acquired gastrointestinal polyposis in childhood cancer survivors, poses diagnostic challenges resembling hereditary syndromes. Four TAP patients were studied, revealing upper gastrointestinal lesions after radiotherapy in 2 patients, managed by endoscopic resection. Two underwent total colectomy; 1 had adenocarcinoma from a polyp. Next-generation sequencing on diseased tissue revealed no alteration in mismatch repair genes with stable microsatellite status; however, there was somatic mutation in APC gene altering Wnt signaling pathway in all 3 precancerous lesions. Integrating endoscopic and surgical interventions is crucial, although ongoing studies aim to elucidate pathophysiology for potential targeted therapies in TAP management.
ISSN:2326-3253
2326-3253
DOI:10.14309/crj.0000000000001379