Interpregnancy Interval After Healthy Live Birth and Subsequent Spontaneous Abortion

Many studies have reported that the interpregnancy interval (IPI) is a potential modifiable risk factor for adverse perinatal outcomes. However, the association between IPI after live birth and subsequent spontaneous abortion (SA) is unclear. To investigate the association of IPI after a healthy liv...

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Published in:JAMA network open 2024-06, Vol.7 (6), p.e2417397
Main Authors: Hu, Xuan, Yang, Ying, Wang, Long, Zhao, Chuanyu, Lyu, Xinyi, Liu, Meiya, Wu, Hanbin, Lei, Jueming, Li, Jiaxin, Yao, Mengxin, Ding, Yaling, Zhang, Hongguang, He, Yuan, Wang, Yuanyuan, Peng, Zuoqi, Shen, Haiping, Wang, Qiaomei, Zhang, Yiping, Yan, Donghai, Yin, Jieyun, Ma, Xu
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Adult
Birth Intervals - statistics & numerical data
China - epidemiology
Cohort analysis
Female
Humans
Live Birth - epidemiology
Middle Aged
Miscarriage
Online Only
Original Investigation
Pregnancy
Prospective Studies
Public Health
Risk Factors
Young Adult
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Summary:Many studies have reported that the interpregnancy interval (IPI) is a potential modifiable risk factor for adverse perinatal outcomes. However, the association between IPI after live birth and subsequent spontaneous abortion (SA) is unclear. To investigate the association of IPI after a healthy live birth and subsequent SA. This prospective cohort study used data from 180 921 women aged 20 to 49 years who had a single healthy live birth and planned for another pregnancy and who participated in the Chinese National Free Prepregnancy Checkups Project from January 1, 2010, to December 31, 2020. Statistical analysis was conducted from June 20 to October 5, 2023. Interpregnancy interval, defined as the interval between the delivery date and conception of the subsequent pregnancy, was categorized as follows: less than 18 months, 18 to 23 months, 24 to 35 months, 36 to 59 months, and 60 months or longer. The main outcome was SA. Multivariable-adjusted odds ratios (ORs) were calculated by logistic regression models to examine the association between IPI and the risk of SA. Dose-response associations were evaluated by restricted cubic splines. The analyses included 180 921 multiparous women (mean [SD] age at current pregnancy, 26.3 [2.8] years); 4380 SA events (2.4% of all participants) were recorded. A J-shaped association between IPI levels and SA was identified. In the fully adjusted model, compared with IPIs of 18 to 23 months, both short (
ISSN:2574-3805
2574-3805
DOI:10.1001/jamanetworkopen.2024.17397