Intraoperative Oxygen Consumption and Postoperative Immune Response in Colorectal Oncological Surgery: A Prospective, Monocentric Pilot Study

• Published in: Journal of personalized medicine 2024-06, Vol.14 (6), p.594
• Main Authors: Ivascu, Robert, Dutu, Madalina, Bucurica, Sandica, Corneci, Dan, Nitipir, Cornelia
• Format: Article
• Language: English
• Subjects: Abdominal wall; Anesthesia; Blood; Blood platelets; Blood transfusions; Calorimetry; Cancer; Care and treatment; Cell activation; Cellular stress response; Colorectal cancer; Colorectal carcinoma; Development and progression; Disease; Electrical equipment and supplies industry; Entropy; Fentanyl; General anesthesia; Immune response; Immune system; Immunology; Leukocytes (neutrophilic); Lymphocytes; Metastasis; Neutrophils; Oncology, Experimental; Oxygen consumption; Patients; Platelets; Statistical analysis; Surgery; Trauma; Tumorigenesis; Variation
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm14060594

Surgical resection is the key treatment for colorectal cancer, but the extent of surgical trauma has been implied as a key factor for the oncologic outcome. The immune stress response to surgical trauma generates a cascade of immunological events implying neutrophils' perioperative change generating NETosis, N killer decrease, and platelets' activation that may influence postoperative surgical outcome, tumor cell growth, and future oncogenesis. The present study aimed to investigate the correlation between intraoperative oxygen consumption (VO ) and the dynamic variation of neutrophils, lymphocytes, and platelets in the perioperative period to identify an intraoperative tool that could predict the postoperative immune response. Twenty-six colorectal oncological surgical patients were enrolled in an observational, prospective, monocentric study, over 18 months. Serum neutrophils, lymphocytes, and thrombocytes values were collected in the preoperative period and on the third postoperative day, oxygen consumption was measured and recorded every 15 min during surgery using indirect calorimetry. We compared oxygen consumption measurements registered 30 min after induction of anesthesia (VO a) and the first value registered after abdominal wall closure (VO b) to perioperative variation of absolute neutrophils (VNC), lymphocytes (VLC), and platelets (VPC) count. Our results proved a significant correlation between VO variation and neutrophils' perioperative dynamic assessed by VNC (correlation coefficient = 0.547, < 0.01, 95% confidence interval (CI) =0.175, 0.783). We also noticed a correlation between VPC and VO (correlation coefficient = -0.603, < 0.01, 95% CI = -0.815, -0.248). No correlation could be shown between VO2 and VLC variation ( = 0.39). In conclusion, intraoperative VO variation measured by indirect calorimetry correlates well with perioperative neutrophils and platelets count dynamic variations and can be used as an early prognosis marker of postoperative immune response and surgical outcome in colorectal oncological surgery.