Differences in Anthropometric, Sleep and Respiratory Characteristics between Hypercapnic and Normocapnic Patients with COPD-OSA Overlap Syndrome

• Published in: Journal of personalized medicine 2024-06, Vol.14 (6), p.600
• Main Authors: Voulgaris, Athanasios, Archontogeorgis, Kostas, Chadia, Konstantina, Siopi, Dimitra, Nena, Evangelia, Steiropoulos, Paschalis
• Format: Article
• Language: English
• Subjects: Apnea; Body mass index; Chronic obstructive pulmonary disease; Coexistence; Electroencephalography; Hypercapnia; Hypoventilation; Hypoxia; Lung diseases; Lung diseases, Obstructive; Patients; Respiratory function; Sleep and wakefulness; Sleep apnea; Sleep apnea syndromes; Sleep disorders; Smoking; Spirometry; Strain gauges; Tobacco
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm14060600

Overlap syndrome (OS), the coexistence of chronic obstructive pulmonary disease and obstructive sleep apnea, is frequently characterized by the presence of daytime hypercapnia (pCO ≥ 45 mmHg). The aim of this study was to investigate potential differences in anthropometric, sleep and respiratory characteristics between hypercapnic and normocapnic patients with OS. Consecutive patients who underwent polysomnography, pulmonary function testing and arterial blood gases and had been diagnosed with OS were enrolled in the study. According to pCO levels in wakefulness, the patients were divided into group A, consisting of OS patients without hypercapnia ( = 108) or group B, consisting of OS patients with hypercapnia ( = 55). The majority of included patients in both groups were males ( = 92 in group A vs. = 50 in group B). Group B had increased BMI ( = 0.001), neck ( = 0.017) and waist circumference ( = 0.013), higher scores in Epworth sleepiness scale (ESS) ( = 0.008), increased sleep efficiency ( = 0.033), oxygen desaturation index ( = 0.004) and time with oxyhemoglobin saturation