The Relationship between Seropositive Rheumatoid Arthritis and Congestive Heart Failure: A Nationwide Longitudinal Cohort Study in Korea

The aim of this nationwide longitudinal cohort study is to determine the risk of congestive heart failure (CHF) associated with a seropositive rheumatoid arthritis (RA) population in Korea. In this study, National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data from 2002 to 2003 w...

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Bibliographic Details
Published in:Journal of personalized medicine 2024-06, Vol.14 (6), p.615
Main Authors: Kim, Yeo Song, Hong, Je Beom, Kim, Hakyung, Sheen, Seung Hun, Han, In-Bo, Kim, Jeong Gyun, Jeun, Sin Soo, Sohn, Seil
Format: Article
Language:English
Subjects:
Age
Arthritis
Cardiovascular disease
Codes
Cohort analysis
Comorbidity
Congestive heart failure
Diabetes
Diabetes mellitus
Dyslipidemia
Heart failure
Hypertension
Ischemia
Medical screening
Metabolic disorders
Mortality
National health insurance
Population studies
Rheumatoid arthritis
Rheumatoid factor
Sex ratio
Variables
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Summary:The aim of this nationwide longitudinal cohort study is to determine the risk of congestive heart failure (CHF) associated with a seropositive rheumatoid arthritis (RA) population in Korea. In this study, National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data from 2002 to 2003 were used. The cohort was followed up with for 12 years until December of 2015. Seropositive RA was defined as a patient prescribed with a disease-modifying anti-rheumatic drug (DMARD) among patients with the International Classification of Diseases code M05 (seropositive RA). Patients who were diagnosed before 2004 were excluded. The seropositive RA group consisted of 2765 patients, and a total of 13,825 patients were in the control group. The Kaplan-Meier method was used to calculate the 12-year CHF incidence rate for each group. A Cox proportional hazards regression analysis was used to estimate the hazard ratio of CHF. The hazard ratio of CHF in the seropositive RA group was 2.41 (95% confidence interval (CI): 1.40-4.14) after adjusting for age and sex. The adjusted hazard ratio of CHF in the seropositive RA group was 2.50 (95% CI: 1.45-4.30) after adjusting for age, sex, income, and comorbidities. In females aged ≥65 and aged
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm14060615