Epidemiology, clinical profiles, and antimicrobial susceptibility of Elizabethkingia meningoseptica infections: Insights from a tertiary care hospital in Saudi Arabia

Objectives: To investigate the incidence rate, clinical characteristics across different age groups, antimicrobial susceptibility, and outcomes of Elizabethkingia meningoseptica (E. meningoseptica) infections. Methods: A retrospective analysis was carried out to include 66 cases with confirmed E. me...

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Published in:Saudi medical journal 2024-08, Vol.45 (8), p.840-847
Main Authors: Alhuthil, Raghad T, Hijazi, Raghad M, Alyabes, Ohoud A, Alsuhaibani, Mohammed A, Gashgarey, Deema A, Binsalamah, Ibrahim M, Aldahmash, Mohammed A, Alghamdi, Salem M, Albanyan, Esam A, Aljumaah, Suliman A, Al-Hajjar, Sami H
Format: Article
Language:English
Subjects:
Cross infection
Drug resistance in microorganisms
Drug therapy
Gram-negative bacterial infections
Medical research
Medicine, Experimental
Nosocomial infections
Original
Patient outcomes
Statistics
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Summary:Objectives: To investigate the incidence rate, clinical characteristics across different age groups, antimicrobial susceptibility, and outcomes of Elizabethkingia meningoseptica (E. meningoseptica) infections. Methods: A retrospective analysis was carried out to include 66 cases with confirmed E. meningoseptica cultures from sterile samples between January 2014 and June 2022 at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia. Results: A total of 66 cases were identified, with an incidence rate of 0.3 per 1000 admissions. Most cases were hospital-acquired (80.3%), primarily in critical care areas. All patients had underlying diseases, with respiratory (40.9%) and cardiovascular (39.4%) diseases being the most common. Minocycline showed the highest susceptibility (96.0%), followed by trimethoprim/sulfamethoxazole (77.0%), whereas tobramycin and colistin were fully resistant. The in-hospital mortality rate was 34.8%, whereas the 28-day mortality rate was 22.7%. Clinical characteristics across age groups showed a higher prevalence of cardiovascular disease in pediatrics than in adults, whereas exposure to mechanical ventilation, immunosuppressive therapy, previous infection, anemia, and in-hospital mortality were reported more frequently in adults (p
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2024.45.8.20240279