Single Institution Experience in the Management of Locally Advanced (pT4) Differentiated Thyroid Carcinomas

• Published in: Annals of surgical oncology 2024-09, Vol.31 (9), p.5515-5524
• Main Authors: Sessa, Luca, De Crea, Carmela, Voloudakis, Nikolaos, Pennestri’, Francesco, Revelli, Luca, Gallucci, Pierpaolo, Perotti, Germano, Tagliaferri, Luca, Rossi, Ernesto, Rossi, Esther Diana, Pontecorvi, Alfredo, Bellantone, Rocco, Raffaelli, Marco
• Format: Article
• Language: English
• Subjects: Adjuvant therapy; Chemotherapy; Endocrine Tumors; Hematoma; Infiltration; Jugular vein; Medicine; Medicine & Public Health; Metastases; Morbidity; Oncology; Radiation therapy; Risk factors; Surgery; Surgical Oncology; Thyroid; Thyroid cancer; Thyroid carcinoma; Thyroid gland; Thyroxine; Tumors
• ISSN: 1068-9265; 1534-4681; 1534-4681
• DOI: 10.1245/s10434-024-15356-z

Background Locally infiltrating (T4) differentiated thyroid carcinomas (DTC) represent a challenge. Surgical strategy and adjuvant therapy should be planned balancing morbidity and oncologic outcome. A series of patients with T4 DTC who underwent multidisciplinary evaluation and treatment is reported. The main study endpoints were the oncologic outcome, complication rates, and risk factors for tumor recurrence. Patients and Methods All DTC cases operated between 2009 and 2021 were reviewed and T4 DTC cases were identified. En bloc resection of inferior laryngeal nerve (ILN), tracheal, and/or internal jugular vein (IJV) was performed in cases of massive infiltration. In cases of pharyngoesophageal junction (PEJ) invasion, the shaving technique was always applied. Results Among 4775 DTC cases, 60 were T4. ILN infiltration was documented in 45 cases (en bloc resection in 9), tracheal infiltration in 14 (tracheal resection in 2), PEJ invasion in 11 (R0 resection in 7 cases and < 1 cm residual tissue in 4 cases), IJV resection in 6, and laryngeal in 2. In total, 11 postoperative ILN palsy, 23 transient hypoparathyroidisms, and 2 hematomas requiring reoperation were registered. Final histology showed 7 pN0, 22 pN1a, and 31 pN1b tumors. Aggressive variants were observed in 47 patients. All but 1 patient underwent radioiodine treatment, 12 underwent adjuvant external beam radiation therapy (EBRT), and 2 underwent chemotherapy. At a median follow-up of 58 months, no tumor-related death was registered, and seven patients required reoperation for recurrence. Tracheal invasion was the only significant factor negatively impacting recurrence ( p = 0.045). Conclusions A multidisciplinary approach is essential for the management of T4 DTC. Individualized and balanced surgical strategy and adjuvant treatments, in particular EBRT, ensure control of locally advanced disease with acceptable morbidity.