Understanding Anxiety in Cervical Dystonia: An Imaging Study

Background Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate. Objective To investigate brain networks associated with anxiety in CD. Methods Twenty‐six subjects with idiopathic CD underwe...

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Bibliographic Details
Published in:Movement disorders clinical practice (Hoboken, N.J.) N.J.), 2024-08, Vol.11 (8), p.1008-1012
Main Authors: Mahajan, Abhimanyu, Stoub, Travis, Gonzalez, David A., Stebbins, Glenn, Gray, Gabrielle, Warner‐Rosen, Tila, Sugar, Dana, Pylypyuk, Caroline, Yu, Mandy, Comella, Cynthia
Format: Article
Language:English
Subjects:
Adult
Aged
Amygdala - diagnostic imaging
Amygdala - pathology
Amygdala - physiopathology
anxiety
Anxiety - diagnostic imaging
Anxiety - physiopathology
Anxiety - psychology
botulinum toxin
Brain - diagnostic imaging
Brain - pathology
Brain - physiopathology
Brief Report
cervical dystonia
Diffusion Tensor Imaging
dystonia
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
personality trait
Torticollis - diagnostic imaging
Torticollis - physiopathology
Torticollis - psychology
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Summary:Background Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate. Objective To investigate brain networks associated with anxiety in CD. Methods Twenty‐six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State–Trait Anxiety Inventory (STAI) state (STAI‐S) and trait (STAI‐T) subscales. Results Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05). Conclusion Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.
ISSN:2330-1619
2330-1619
DOI:10.1002/mdc3.14070