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Understanding Anxiety in Cervical Dystonia: An Imaging Study
Background Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate. Objective To investigate brain networks associated with anxiety in CD. Methods Twenty‐six subjects with idiopathic CD underwe...
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| Published in: | Movement disorders clinical practice (Hoboken, N.J.) N.J.), 2024-08, Vol.11 (8), p.1008-1012 |
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| container_end_page | 1012 |
| container_issue | 8 |
| container_start_page | 1008 |
| container_title | Movement disorders clinical practice (Hoboken, N.J.) |
| container_volume | 11 |
| creator | Mahajan, Abhimanyu Stoub, Travis Gonzalez, David A. Stebbins, Glenn Gray, Gabrielle Warner‐Rosen, Tila Sugar, Dana Pylypyuk, Caroline Yu, Mandy Comella, Cynthia |
| description | Background
Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate.
Objective
To investigate brain networks associated with anxiety in CD.
Methods
Twenty‐six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State–Trait Anxiety Inventory (STAI) state (STAI‐S) and trait (STAI‐T) subscales.
Results
Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
Conclusion
Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD. |
| doi_str_mv | 10.1002/mdc3.14070 |
| format | article |
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Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate.
Objective
To investigate brain networks associated with anxiety in CD.
Methods
Twenty‐six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State–Trait Anxiety Inventory (STAI) state (STAI‐S) and trait (STAI‐T) subscales.
Results
Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
Conclusion
Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.</description><identifier>ISSN: 2330-1619</identifier><identifier>EISSN: 2330-1619</identifier><identifier>DOI: 10.1002/mdc3.14070</identifier><identifier>PMID: 38747154</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Amygdala - diagnostic imaging ; Amygdala - pathology ; Amygdala - physiopathology ; anxiety ; Anxiety - diagnostic imaging ; Anxiety - physiopathology ; Anxiety - psychology ; botulinum toxin ; Brain - diagnostic imaging ; Brain - pathology ; Brain - physiopathology ; Brief Report ; cervical dystonia ; Diffusion Tensor Imaging ; dystonia ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; personality trait ; Torticollis - diagnostic imaging ; Torticollis - physiopathology ; Torticollis - psychology</subject><ispartof>Movement disorders clinical practice (Hoboken, N.J.), 2024-08, Vol.11 (8), p.1008-1012</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</rights><rights>2024 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4080-1cb4bff3dabe2459bcacc685be6dbde3160b060146846d063bd64f729fc82aaa3</cites><orcidid>0000-0003-0882-7689 ; 0000-0001-8807-6672</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38747154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahajan, Abhimanyu</creatorcontrib><creatorcontrib>Stoub, Travis</creatorcontrib><creatorcontrib>Gonzalez, David A.</creatorcontrib><creatorcontrib>Stebbins, Glenn</creatorcontrib><creatorcontrib>Gray, Gabrielle</creatorcontrib><creatorcontrib>Warner‐Rosen, Tila</creatorcontrib><creatorcontrib>Sugar, Dana</creatorcontrib><creatorcontrib>Pylypyuk, Caroline</creatorcontrib><creatorcontrib>Yu, Mandy</creatorcontrib><creatorcontrib>Comella, Cynthia</creatorcontrib><title>Understanding Anxiety in Cervical Dystonia: An Imaging Study</title><title>Movement disorders clinical practice (Hoboken, N.J.)</title><addtitle>Mov Disord Clin Pract</addtitle><description>Background
Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate.
Objective
To investigate brain networks associated with anxiety in CD.
Methods
Twenty‐six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State–Trait Anxiety Inventory (STAI) state (STAI‐S) and trait (STAI‐T) subscales.
Results
Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
Conclusion
Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.</description><subject>Adult</subject><subject>Aged</subject><subject>Amygdala - diagnostic imaging</subject><subject>Amygdala - pathology</subject><subject>Amygdala - physiopathology</subject><subject>anxiety</subject><subject>Anxiety - diagnostic imaging</subject><subject>Anxiety - physiopathology</subject><subject>Anxiety - psychology</subject><subject>botulinum toxin</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brief Report</subject><subject>cervical dystonia</subject><subject>Diffusion Tensor Imaging</subject><subject>dystonia</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>personality trait</subject><subject>Torticollis - diagnostic imaging</subject><subject>Torticollis - physiopathology</subject><subject>Torticollis - psychology</subject><issn>2330-1619</issn><issn>2330-1619</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp9kV1L3EAUhodSqWL3xh9QAr0phbXnZCaTpBSKrFYFxQv1epivbEeSiZ1J1Px7Z7urqBdyLubAeXh4h5eQPYR9BMh_dEbTfWRQwgeyk1MKc-RYf3yxb5NZjDcAgHnBIcdPZJtWJSuxYDvk17U3NsRBeuP8MjvwD84OU-Z8trDhzmnZZodTHHrv5M90zU47uVyBl8Nops9kq5FttLPNu0uu_xxdLU7mZxfHp4uDs7lmUKUQWjHVNNRIZXNW1EpLrXlVKMuNMpYiBwUckPGKcQOcKsNZU-Z1o6tcSkl3ye-193ZUnTXa-iHIVtwG18kwiV468fri3V-x7O8EIs3rgmMyfNsYQv9vtHEQnYvatq30th-joFAULA2yhH59g970Y_Dpf4mqaQkUWZmo72tKhz7GYJvnNAhiVYxYFSP-F5PgLy_zP6NPNSQA18C9a-30jkqcHy7oWvoIQWyXLw</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Mahajan, Abhimanyu</creator><creator>Stoub, Travis</creator><creator>Gonzalez, David A.</creator><creator>Stebbins, Glenn</creator><creator>Gray, Gabrielle</creator><creator>Warner‐Rosen, Tila</creator><creator>Sugar, Dana</creator><creator>Pylypyuk, Caroline</creator><creator>Yu, Mandy</creator><creator>Comella, Cynthia</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0882-7689</orcidid><orcidid>https://orcid.org/0000-0001-8807-6672</orcidid></search><sort><creationdate>202408</creationdate><title>Understanding Anxiety in Cervical Dystonia: An Imaging Study</title><author>Mahajan, Abhimanyu ; Stoub, Travis ; Gonzalez, David A. ; Stebbins, Glenn ; Gray, Gabrielle ; Warner‐Rosen, Tila ; Sugar, Dana ; Pylypyuk, Caroline ; Yu, Mandy ; Comella, Cynthia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4080-1cb4bff3dabe2459bcacc685be6dbde3160b060146846d063bd64f729fc82aaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amygdala - diagnostic imaging</topic><topic>Amygdala - pathology</topic><topic>Amygdala - physiopathology</topic><topic>anxiety</topic><topic>Anxiety - diagnostic imaging</topic><topic>Anxiety - physiopathology</topic><topic>Anxiety - psychology</topic><topic>botulinum toxin</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brief Report</topic><topic>cervical dystonia</topic><topic>Diffusion Tensor Imaging</topic><topic>dystonia</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>personality trait</topic><topic>Torticollis - diagnostic imaging</topic><topic>Torticollis - physiopathology</topic><topic>Torticollis - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahajan, Abhimanyu</creatorcontrib><creatorcontrib>Stoub, Travis</creatorcontrib><creatorcontrib>Gonzalez, David A.</creatorcontrib><creatorcontrib>Stebbins, Glenn</creatorcontrib><creatorcontrib>Gray, Gabrielle</creatorcontrib><creatorcontrib>Warner‐Rosen, Tila</creatorcontrib><creatorcontrib>Sugar, Dana</creatorcontrib><creatorcontrib>Pylypyuk, Caroline</creatorcontrib><creatorcontrib>Yu, Mandy</creatorcontrib><creatorcontrib>Comella, Cynthia</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Online Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Movement disorders clinical practice (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahajan, Abhimanyu</au><au>Stoub, Travis</au><au>Gonzalez, David A.</au><au>Stebbins, Glenn</au><au>Gray, Gabrielle</au><au>Warner‐Rosen, Tila</au><au>Sugar, Dana</au><au>Pylypyuk, Caroline</au><au>Yu, Mandy</au><au>Comella, Cynthia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding Anxiety in Cervical Dystonia: An Imaging Study</atitle><jtitle>Movement disorders clinical practice (Hoboken, N.J.)</jtitle><addtitle>Mov Disord Clin Pract</addtitle><date>2024-08</date><risdate>2024</risdate><volume>11</volume><issue>8</issue><spage>1008</spage><epage>1012</epage><pages>1008-1012</pages><issn>2330-1619</issn><eissn>2330-1619</eissn><abstract>Background
Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate.
Objective
To investigate brain networks associated with anxiety in CD.
Methods
Twenty‐six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State–Trait Anxiety Inventory (STAI) state (STAI‐S) and trait (STAI‐T) subscales.
Results
Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
Conclusion
Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38747154</pmid><doi>10.1002/mdc3.14070</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0882-7689</orcidid><orcidid>https://orcid.org/0000-0001-8807-6672</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Amygdala - diagnostic imaging Amygdala - pathology Amygdala - physiopathology anxiety Anxiety - diagnostic imaging Anxiety - physiopathology Anxiety - psychology botulinum toxin Brain - diagnostic imaging Brain - pathology Brain - physiopathology Brief Report cervical dystonia Diffusion Tensor Imaging dystonia Female Humans Magnetic Resonance Imaging Male Middle Aged personality trait Torticollis - diagnostic imaging Torticollis - physiopathology Torticollis - psychology |
| title | Understanding Anxiety in Cervical Dystonia: An Imaging Study |
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