Associations Between Severe Influenza‐Complicated Thromboembolism Events, Intensive Care Unit Stays and Mortality, and Associated Risk Factors: A Retrospective Cohort Study

• Published in: Influenza and other respiratory viruses 2024-09, Vol.18 (9), p.e13354-n/a
• Main Authors: Lee, Wei‐Chun, Chang, Che‐Chia, Ho, Meng‐Chin, Lin, Chin‐Kuo, Lin, Chieh‐Mo, Fang, Yu‐Hung, Huang, Shu‐Yi, Lin, Yu‐Ching, Chuang, Min‐Chun, Yang, Tsung‐Ming, Hung, Ming‐Szu, Chou, Yen‐Li, Tsai, Ying‐Huang, Hsieh, Meng‐Jer
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Body mass index; Cardiovascular disease; Cerebrovascular disease; Chronic obstructive pulmonary disease; Community-Acquired Infections - complications; Community-Acquired Infections - epidemiology; Community-Acquired Infections - mortality; community‐acquired pneumonia; Embolism; Female; Health risks; Humans; Hypertension; Influenza; Influenza, Human - complications; Influenza, Human - mortality; intensive care stay; Intensive Care Units - statistics & numerical data; Kidney diseases; Length of Stay - statistics & numerical data; Male; Mechanical ventilation; Middle Aged; Mortality; Original; Pulmonary embolisms; Regression analysis; Respiration, Artificial - statistics & numerical data; Retrospective Studies; Risk Factors; Taiwan - epidemiology; Thromboembolism; Thromboembolism - epidemiology; Thromboembolism - etiology; Thromboembolism - mortality; thromboembolism disease; Thrombosis; Ventilation; Ventilators
• ISSN: 1750-2640; 1750-2659; 1750-2659
• DOI: 10.1111/irv.13354

ABSTRACT The association between influenza infection and thromboembolism (TE) events, including cardiovascular events, cerebrovascular events, pulmonary embolism, and deep vein thrombosis, is supported by compelling evidence. However, there is a disparity in the risk factors that impact the outcomes of severe influenza‐complicated TE in intensive care unit (ICU) patients. The objective of this study was to evaluate the outcomes of severe influenza‐complicated TE in ICU patients and identify any associated risk factors. Methods A retrospective cohort study was conducted, recruiting consecutive patients with TE events admitted to the ICU between December 2015 through December 2018 at our institution in Taiwan. The study included a group of 108 patients with severe influenza and a control group of 192 patients with severe community‐acquired pneumonia. Associations between complicated TE, length of ICU stay, and 90‐day mortality were evaluated using logistic regression analysis, and risk factors were identified using univariate and multivariate generalized linear regression analyses. Results TE event prevalence was significantly higher in ICU patients with severe influenza than in ICU patients with severe CAP (21.3% vs. 5.7%, respectively; p