Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study

Background Previous observational studies have revealed a potentially robust bidirectional relationship between frailty and low back pain (LBP). However, the precise causal relationship remains unclear. Methods To examine the potential causal association between frailty and LBP, we conducted bidirec...

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Published in:Aging clinical and experimental research 2024-09, Vol.36 (1), p.191, Article 191
Main Authors: Liu, Zuying, Fan, Jiaming, Bu, Huilian, Fu, Lijun, Li, Cong, Ma, Letian, Kong, Cunlong, Lu, Zhongyuan, Li, Xinxin, Wang, Jian, Liu, Qingying, Yuan, Jingjing, Fan, Xiaochong
Format: Article
Language:English
Subjects:
Aged
Back pain
Causality
Female
Frailty
Frailty - genetics
Genome-Wide Association Study
Geriatrics/Gerontology
Humans
Low Back Pain - epidemiology
Low Back Pain - genetics
Medicine
Medicine & Public Health
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
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Summary:Background Previous observational studies have revealed a potentially robust bidirectional relationship between frailty and low back pain (LBP). However, the precise causal relationship remains unclear. Methods To examine the potential causal association between frailty and LBP, we conducted bidirectional two-sample Mendelian randomization analysis (MR) study. Genetic data on frailty index (FI) and LBP were acquired from publicly available genome-wide association studies (GWAS). Various MR methodologies were utilized, such as inverse variance weighting (IVW), weighted median, and MR-Egger, to evaluate causality. Additionally, sensitivity analyses were conducted to evaluate the robustness of the findings. Results Genetically predicted higher FI (IVW, odds ratio [OR] = 1.66, 95% CI 1.17–2.36, p  = 4.92E-03) was associated with a higher risk of LBP. As for the reverse direction, genetic liability to LBP showed consistent associations with a higher FI (IVW, OR = 1.13, 95% CI 1.07–1.19, p  = 2.67E-05). The outcomes from various MR techniques and sensitivity analyses indicate the robustness of our findings. Conclusion Our research findings provide additional evidence bolstering the bidirectional causal relationship between frailty and LBP.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-024-02843-2