Research on the soothing Liver - Qi stagnation method in the treatment of postoperative papillary thyroid carcinoma patients' concomitant depression: A randomized controlled clinical trial

Postoperative papillary thyroid carcinoma (P-PTC) patients often grapple with depression fueled by the looming threat of recurrence. While the Liver-Qi stagnation method is frequently employed for depression management, a notable scarcity of clinical trials exists regarding its application in patien...

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Bibliographic Details
Published in:Medicine (Baltimore) 2024-09, Vol.103 (37), p.e39325
Main Authors: Lin, Huiyue, Zhang, Xueting, Zheng, Yuqian, Tang, Chenchen, Wang, Juyong
Format: Article
Language:English
Subjects:
Adult
Clinical Trial/Experimental Study
Depression - drug therapy
Depression - etiology
Drugs, Chinese Herbal - therapeutic use
Female
Humans
Liver
Male
Medicine, Chinese Traditional - methods
Middle Aged
Postoperative Complications - drug therapy
Quality of Life
Serotonin - blood
Thyroid Cancer, Papillary - surgery
Thyroid Neoplasms - surgery
Treatment Outcome
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Summary:Postoperative papillary thyroid carcinoma (P-PTC) patients often grapple with depression fueled by the looming threat of recurrence. While the Liver-Qi stagnation method is frequently employed for depression management, a notable scarcity of clinical trials exists regarding its application in patients with P-PTC and concurrent depression. This study presents a randomized controlled clinical trial, aiming to establish the efficacy of the Liver-Qi stagnation method in alleviating depression in patients with P-PTC. In this randomized controlled clinical trial, P-PTC patients diagnosed with concomitant depression were systematically enrolled. Subjects were randomly assigned to either the control or test group, both receiving standard treatment comprising Levothyroxine sodium tablets and decoction of benefiting Qi and nourishing Yin. Additionally, the test group received supplementation with bupleuri radix-paeoniae alba radix (CH-BS) alongside the baseline therapy. The intervention spanned 12 weeks. Pre- and post-treatment evaluations were conducted using the Hamilton Depression Scale (HAMD), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Traditional Chinese Medicine (TCM) syndrome score scale. Concurrently, blood inflammatory factors and serum 5-hydroxytryptamine (5-HT) levels were measured to comprehensively assess treatment outcomes. During the 12-week intervention, the test group demonstrated a significant reduction in HAMD scores compared to the control group (P 
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000039325