Genomic Regions Associated with Growth and Reproduction Traits in Pink-Eyed White Mink

In mink breeding, balanced selection for growth and reproductive features is essential because these traits are contradictory. The variables of total number born (TNB), number born alive (NBA), and body weight (BW) are highly valuable in terms of their importance in mink production. A comprehensive...

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Bibliographic Details
Published in:Genes 2024-08, Vol.15 (9), p.1142
Main Authors: Shi, Hongyu, Liu, Linling, Larsen, Peter Foged, Ding, Yu, Zhang, Tietao, Zhang, Haihua, Liu, Zongyue
Format: Article
Language:English
Subjects:
Albinism
Animals
Body weight
Body Weight - genetics
Breeding
Chromosomes
DNA sequencing
Female
Gene polymorphism
Genes
Genetic markers
Genome-wide association studies
Genome-Wide Association Study - veterinary
Genomes
Genotype
Haplotypes
Laboratory animals
Localization
Male
Mink - genetics
Mink - growth & development
Molecular modelling
NF-κB protein
Phenotype
Phenotypes
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Reproduction - genetics
Single-nucleotide polymorphism
Software
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Summary:In mink breeding, balanced selection for growth and reproductive features is essential because these traits are contradictory. The variables of total number born (TNB), number born alive (NBA), and body weight (BW) are highly valuable in terms of their importance in mink production. A comprehensive understanding of the molecular mechanisms that drive these features could offer vital insights into their genetic compositions. In the present study, the single-nucleotide polymorphism (SNP) genotypes of 219 minks were obtained via double digest restriction-site associated DNA sequencing (ddRAD-seq). Following several rounds of screening, about 2,415,121 high-quality SNPs were selected for a genome-wide association study (GWAS). The GWAS was used to determine BW and reproductive traits in pink-eyed white mink. It was suggested that , , and serve as potential genes for the total number of kits born (TNB), while , , , , , and are key genes for the number born alive (NBA). Moreover, , , , and are possible BW genes based on association results and available functional data from gene and mammalian phenotype databases. These results offer essential information about the variety of mink and theoretical principles for applying mink breeds.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes15091142