The Epitope Basis of Embryonic Stem Cell‐Induced Antitumor Immunity against Bladder Cancer

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) share many cellular and molecular features with cancer cells. Taking advantage of these similarities, stem cells are effective vaccines against cancers in animal models. However, the molecular basis is not well understood, which...

Full description

Saved in:
Bibliographic Details
Published in:Advanced healthcare materials 2023-04, Vol.12 (9), p.e2202691-n/a
Main Authors: Jin, Meiling, Hu, Jingchu, Tong, Lili, Zhang, Bao‐Zhong, Huang, Jian‐Dong
Format: Article
Language:English
Subjects:
Animal models
Animals
Bladder
Bladder cancer
Cancer Vaccines
CD4 antigen
CD8 antigen
CD8-Positive T-Lymphocytes
Colony-stimulating factor
Cytotoxicity
Embryo cells
Embryonic Stem Cells
Epitopes
Granulocyte-macrophage colony-stimulating factor
Immunity
Immunological memory
Leukocytes (granulocytic)
Lymphocytes
Lymphocytes T
Macrophages
Memory cells
Mice
Molecular modelling
Pluripotency
Stem cells
Suppressor cells
tumor immunity
Urinary Bladder Neoplasms - therapy
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) share many cellular and molecular features with cancer cells. Taking advantage of these similarities, stem cells are effective vaccines against cancers in animal models. However, the molecular basis is not well understood, which hinders the development of effective cancer vaccines. Here, prophylactic and therapeutic bladder cancer vaccines composed of allogeneic ESCs and CpG with or without granulocyte macrophage colony stimulating factor are tested. The ESC‐based cancer vaccines are able to induce specific antitumor immunity including stimulating cytotoxic CD8+ T cells and memory CD4+ T cells, reducing myeloid‐derived suppressor cells, and preventing bladder cancer growth in mouse models. Furthermore, several genes that are overexpressed in both ESCs and tumors are identified. An epitope‐based vaccine designed with shared overexpressed proteins induces specific antitumor immunity and reduces bladder cancer growth. Functional epitopes underlying the action of stem cell‐based vaccines against bladder cancer are identified and it is confirmed that ESC‐based anticancer vaccines have great potential. A systematic approach is provided here to developing novel effective epitope‐based cancer vaccines in the future. Embryonic stem cell (ESC)‐based vaccines stimulate cytotoxic T‐cell immunity and prevent bladder cancer growth. A platform is established to systematically identify the shared tumor‐associated antigens and CD8+ T cell epitopes expressed in ESCs and tumor cells. The antitumor effects of these peptides are validated which may be used for further cancer therapy.
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.202202691