New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor

Thirteen years after kidney donation, a 70-year-old man was referred to a nephrologist because of proteinuria. The serum creatinine, albumin, and urinary protein levels were 2.39 mg/dL, 3.0 g/dL, and 6.72 g/gCr, respectively. A kidney biopsy revealed thickening of the glomerular basement membrane wi...

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Bibliographic Details
Published in:Internal Medicine 2024/09/15, Vol.63(18), pp.2537-2541
Main Authors: Morioka, Fumiyuki, Nakatani, Shinya, Mori, Katsuhito, Naganuma, Toshihide, Yamasaki, Takeshi, Uedono, Hideki, Tsuda, Akihiro, Ishimura, Eiji, Uchida, Junji, Emoto, Masanori
Format: Article
Language:English
Subjects:
Aged
Basement membranes
Biopsy
Case Report
Creatinine
End-stage renal disease
Fibrosis
Glomerulonephritis, Membranous - diagnosis
Glomerulonephritis, Membranous - etiology
Glomerulonephritis, Membranous - pathology
Hemodialysis
Humans
Kidney - pathology
kidney biopsy
Kidney diseases
Kidney Failure, Chronic - complications
Kidney Transplantation - adverse effects
Living Donors
living kidney donor
Male
Membranous nephropathy
Nephropathy
Proteinuria
Renal Dialysis - adverse effects
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Summary:Thirteen years after kidney donation, a 70-year-old man was referred to a nephrologist because of proteinuria. The serum creatinine, albumin, and urinary protein levels were 2.39 mg/dL, 3.0 g/dL, and 6.72 g/gCr, respectively. A kidney biopsy revealed thickening of the glomerular basement membrane with sub-epithelial deposits, suggesting membranous nephropathy. Considering the apparent interstitial fibrosis and diffuse glomerulosclerosis, supportive treatment was chosen. However, 11 months after the kidney biopsy, hemodialysis was required. The present case constitutes an important teaching point, as glomerular disease can occur in living donors and require careful and long-term medical checkup examinations.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.2814-23