The Association of IFNL4 Gene Polymorphisms with Hepatitis B Virus (HBV) Infection in the Northern Region of Pará, Brazil

It is heavily suggested that one gene polymorphism, rs12979860 (T/C), exerts influence on the outcome of HBV infection, with the rs12979860-T allele being classified as a risk predictor, and the rs12979860-C allele being classified as a protective one. This study investigated whether the rs12979860...

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Published in:International journal of molecular sciences 2024-10, Vol.25 (19), p.10836
Main Authors: Andrade, Álesson Adam Fonseca, Angelim, Carolina Cabral, Martins, Letícia Dias, Sacramento, Amanda Roberta Vieira, Sousa, Renata Santos de, Correa, Raissa Lima, Conde, Simone Regina Souza da Silva, Vallinoto, Antonio Carlos Rosário, Feitosa, Rosimar Neris Martins, Costa, Greice de Lemos Cardoso
Format: Article
Language:English
Subjects:
Adult
Alleles
Asymptomatic
Brazil - epidemiology
Female
Gene Frequency
Genetic aspects
Genetic Predisposition to Disease
Genotype
Health aspects
Health care
Hepatitis B
Hepatitis B - genetics
Hepatitis B - virology
Hepatitis B virus - genetics
Humans
Infections
Interferon
Interferon Lambda
Interleukins - genetics
Liver cirrhosis
Male
Middle Aged
Physiological aspects
Polymorphism
Polymorphism, Single Nucleotide
Prognosis
Risk factors
Single nucleotide polymorphisms
Viral infections
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Summary:It is heavily suggested that one gene polymorphism, rs12979860 (T/C), exerts influence on the outcome of HBV infection, with the rs12979860-T allele being classified as a risk predictor, and the rs12979860-C allele being classified as a protective one. This study investigated whether the rs12979860 gene polymorphism presented any association with the clinical severity for HBV carriers in an admixed population in Northern Brazil. A total of 69 samples were investigated from infected people from the city of Belém-Pará. The rs12979860-T allele was positively associated with HBV infection, suggesting a higher risk of chronicity. This research's importance is that the polymorphism influence was investigated in a population of HBV carriers with a heterogeneous genetic profile, formed through the extensive admixture of different ethnic groups, including Europeans, Africans, and Natives with indigenous heritage. This analysis is particularly important since highly mixed populations do not always follow the same association patterns previously established by studies using populations classified as more genetically homogeneous, due to a different formation process.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms251910836