Psychosocial implications of learning amyloid PET results in an observational cohort

INTRODUCTION Information on the psychosocial impact of Alzheimer's disease (AD) biomarker testing in adults at risk of AD is needed to inform best practices for communicating biomarker results. METHODS Ninety‐nine cognitively unimpaired older adults learned amyloid positron emission tomography...

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Published in:Alzheimer's & dementia 2024-09, Vol.20 (9), p.6579-6589
Main Authors: Clark, Lindsay R., Erickson, Claire M., Chin, Nathaniel A., Basche, Kristin E., Ketchum, Fred B., Rosario, Hannah L., Peterson, Amanda J., Eveler, Marcella L., Johnson, Sterling C.
Format: Article
Language:English
Subjects:
advanced planning
Aged
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - psychology
Alzheimer's
amyloid
Amyloid - metabolism
biomarker disclosure
Biomarkers
cognition
Cohort Studies
dementia
Female
Humans
Learning - physiology
Male
perceived risk
Positron-Emission Tomography
psychological
psychosocial
risk communication
test‐related distress
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Summary:INTRODUCTION Information on the psychosocial impact of Alzheimer's disease (AD) biomarker testing in adults at risk of AD is needed to inform best practices for communicating biomarker results. METHODS Ninety‐nine cognitively unimpaired older adults learned amyloid positron emission tomography (PET) results (mean age = 72.0 ± 4.8, 95% White, 28% elevated amyloid). Linear mixed‐effects regression models were used to test the main effects and interaction of PET result × time on psychosocial outcomes up to 6 months after learning results. RESULTS A significant interaction of PET result × time was observed for concern about AD (β = 0.28, p = 0.02) and intrusive thoughts and avoidance (β = ‐0.82, p 
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.14153