Alterations of gut microbiome in eosinophilic chronic rhinosinusitis

• Published in: European archives of oto-rhino-laryngology 2024-12, Vol.281 (12), p.6459-6468
• Main Authors: Liang, Yibo, Zhang, Chenting, Xiong, Xin, Mao, Xiang, Sun, Peiyong, Yue, Zhenzhong, Wang, Wei, Xie, Runxiang, Zhang, Guimin
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Chronic Disease; Cross-Sectional Studies; Eosinophilia - microbiology; Female; Gastrointestinal Microbiome; Head and Neck Surgery; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Nasal Polyps - microbiology; Neurosurgery; Otorhinolaryngology; Rhinitis - microbiology; Rhinology; Rhinosinusitis; RNA, Ribosomal, 16S - genetics; Sinusitis - microbiology
• ISSN: 0937-4477; 1434-4726; 1434-4726
• DOI: 10.1007/s00405-024-08931-3

Purpose A growing body of evidence has elucidated that the gut microbiota has a crucial impact on the pathophysiological process of atopic diseases. Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is a local atopic disease of the systemic immune response. Alterations in the gut microbiome in eCRSwNP patients remain largely undefined. Methods 16S rRNA gene sequencing was performed in a cross-sectional study of 17 eCRSwNP patients, 9 noneCRSwNP patients and 13 healthy controls, and gut microbiota DNA sequencing between each pair of groups was compared using bioinformatic methods. Results Compared with that of healthy controls, the gut microbiomes of eCRSwNP patients were characterised by a distinct overall microbial composition. However, no significant differences were found in the alpha diversity of the gut microbiota between patients and healthy controls. The distinct differences in microbial composition were significantly correlated with the severity of disease. At the genus level, the abundance of Faecalibacterium positively correlated with Lund-Mackay CT scores. Similarly, the abundance of Turicibacter positively correlated with the percentage of tissue eosinophils. Conclusions We found alterations in the gut microbiome in eCRSwNP patients, and the alterations in the gut microbiome were correlated with the severity of disease.