Severe Radiation-Induced Brachial Plexopathy: A Case Report on Radiation Toxicity in a Patient With Invasive Ductal Carcinoma

The ataxia-telangiectasia mutated ( ) gene is an important regulator of cell checkpoint signaling and the repair of double-stranded breaks. When the gene is mutated or damaged, cells are less capable of responding to damage induced by radiation therapy (RT). Here, we present a case of a 50-year-old...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-11, Vol.16 (11), p.e73043
Main Authors: Waeldner, Kathleen, Chin, Christine, Gilbo, Philip
Format: Article
Language:English
Subjects:
Genetics
Oncology
Radiation Oncology
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Summary:The ataxia-telangiectasia mutated ( ) gene is an important regulator of cell checkpoint signaling and the repair of double-stranded breaks. When the gene is mutated or damaged, cells are less capable of responding to damage induced by radiation therapy (RT). Here, we present a case of a 50-year-old woman with stage IIIA invasive ductal carcinoma of the left breast who had genetic testing revealing pathogenic mutations (c.5290del and c.4396C>G) and a mutation (c.1619dup). While guidelines suggest that adjuvant radiation therapy is safe for patients with mutations, this patient experienced severe radiation-induced toxicities, including brachial plexopathy. These mutations have not previously been described as imparting severe radiation-associated toxicities.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.73043