Comparison of the efficacy and safety of a 730‐nm picosecond titanium sapphire laser and a 1064‐nm picosecond neodymium yttrium aluminum garnet laser for the treatment of acquired bilateral nevus of Ota‐like macules: A split‐face, evaluator‐blinded, randomized, and controlled pilot trial

• Published in: Journal of cosmetic dermatology 2024-12, Vol.23 (12), p.3961-3967
• Main Authors: Chen, Wanxin, Wang, Zhongshuai, Li, Zhenzhen, Yuan, Chen, Zhang, Xiaofeng, Li, Li, Yan, Yan, Wang, Baoxi
• Format: Article
• Language: English
• Subjects: acquired bilateral nevus of Ota‐like macules; Adult; Energy Based Devices; Female; Hori's nevus; Humans; Lasers, Solid-State - adverse effects; Lasers, Solid-State - therapeutic use; Low-Level Light Therapy - adverse effects; Low-Level Light Therapy - instrumentation; Low-Level Light Therapy - methods; Male; Middle Aged; Nevus of Ota - radiotherapy; Original; Patient Satisfaction; picosecond laser; Pilot Projects; Single-Blind Method; Skin Neoplasms - radiotherapy; Skin Neoplasms - surgery; titanium sapphire laser; Treatment Outcome; Young Adult
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.16511

Background The picosecond neodymium yttrium aluminum garnet laser (PNYL) has been successfully used in treating acquired bilateral nevus of Ota‐like macules (ABNOM). The 730‐nm picosecond titanium sapphire laser (PTSL) is an emerging tool for pigmentary disorders. However, no studies have compared two different wavelengths of picosecond laser for the treatment of ABNOM. Aims To compare the efficacy and safety of the 730‐nm PTSL with the 1064‐nm PNYL in the treatment of ABNOM. Methods Fifteen participants with ABNOM were randomized to undergo a single session of either the 730‐nm PTSL on one side of the face and 1064‐nm PNYL on the other side. Efficacy and safety assessments were performed by blinded visual evaluations at baseline, 12 weeks, and 24 weeks posttreatment. Participants' satisfaction and adverse effects were recorded. Results Compared to baseline, The 730‐nm PTSL‐treated side showed better improvement than that of the 1064‐nm PNYL‐treated side at 24 weeks posttreatment (1.67 ± 1.047 vs. 0.87 ± 0.640, p = 0.027). There were no significant differences in pain sensation and participants' satisfaction between the two laser treatments. Conclusions The 730‐nm PTSL is more effective than the 1064‐nm PNYL in the treatment of ABNOM.