Benefits of natural edible ingredients in epidermal permeability barrier function

• Published in: Chinese medical journal 2024-09, Vol.137 (23), p.2868-2870
• Main Authors: Lei, Dongyun, Liu, Xiaojie, Zhang, Ting, Chen, Jiaxing, Zhang, Junling, Zhang, Litao
• Format: Article
• Language: English
• Subjects: Antioxidants; Collagen; Cytokines; Fatty acids; Hyaluronic acid; Inflammation; Lipids; Oral administration; Peptides; Permeability; Polyphenols; Probiotics; Proteins; Skin
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.1097/CM9.0000000000003208

[7] Taken together, the evidence indicates the regulatory role of epidermal function in cutaneous and extracutaneous functions. [...]improvement in epidermal function can benefit the overall human health. Studies have also demonstrated the benefit of oral administration of herbal mixtures or hyaluronic acid in epidermal permeability barrier function. [...]a number of natural edible ingredients can improve epidermal permeability barrier function. [...]oral ceramide increases ceramide content in the stratum corneum (SC) of mice, suggesting oral ceramide, and possibly other lipids, can be carried by the blood to the epidermis, where it is utilized for the formation of the permeability barrier. Lysates of Lactobacillus rhamnosus can also increase the expression levels of tight junction proteins and differentiation marker-related proteins, and prevent degradation of the desmosome, another key determinant of the epidermal permeability barrier function. [...]anti-inflammation and indirect upregulation of keratinocyte differentiation and tight junctions account, at least in part, for the mechanisms by which some natural edible ingredients improve epidermal permeability barrier function. [...]some topical skincare products can cause adverse cutaneous reactions.