Research progress on the relationship between traumatic brain injury and brain‐gut‐microbial axis

• Published in: Ibrain 2024-03, Vol.10 (4), p.477-487
• Main Authors: Yu, Jie, Chen, Yun‐Xin, Wang, Jin‐Wei, Wu, Hai‐Tao
• Format: Article
• Language: English
• Subjects: brain‐gut‐microbial axis; fecal microbiota transplantations; microbes; nervous system; Review; traumatic brain injury
• ISSN: 2313-1934; 2769-2795
• DOI: 10.1002/ibra.12153

Traumatic brain injury (TBI) is a common disease with a high rate of death and disability, which poses a serious threat to human health; thus, the effective treatment of TBI has been a high priority. The brain‐gut‐microbial (BGM) axis, as a bidirectional communication network for information exchange between the brain and gut, plays a crucial role in neurological diseases. This article comprehensively explores the interrelationship between the BGM axis and TBI, including its physiological effects, basic pathophysiology, and potential therapeutic strategies. It highlights how the bidirectional regulatory pathways of the BGM axis could provide new insights into clinical TBI treatment and underscores the necessity for advanced research and development of innovative clinical treatments for TBI. Here, we review the relationship between the brain and the gut following craniocerebral trauma, and we examine the brain‐gut‐microbial axis pathway. Our aim is to propose potential treatments for traumatic brain injury (TBI), including microbial intervention, microbiota transplantation, vagus nerve stimulation, and so forth, with the hope that they may be applied in clinical practice in the future to provide greater benefits to TBI patients.