KTED: a comprehensive web-based database for transposable elements in the Korean genome

Transposable elements (TEs), commonly referred to as "mobile elements," constitute DNA segments capable of relocating within a genome. Initially disregarded as "junk DNA" devoid of specific functionality, it has become evident that TEs have diverse influences on an organism'...

Full description

Saved in:
Bibliographic Details
Published in:Bioinformatics advances 2024, Vol.4 (1), p.vbae179
Main Authors: Lee, Jin-Ok, Lee, Sejoon, Lee, Dongyoon, Hwang, Taeyeon, Joe, Soobok, Yang, Jin Ok, Jeong, Jibin, Ohn, Jung Hun, Kim, Jee Hyun
Format: Article
Language:English
Subjects:
Application Note
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transposable elements (TEs), commonly referred to as "mobile elements," constitute DNA segments capable of relocating within a genome. Initially disregarded as "junk DNA" devoid of specific functionality, it has become evident that TEs have diverse influences on an organism's biology and health. The impact of these elements varies according to their location, classification, and their effects on specific genes or regulatory components. Despite their significant roles, a paucity of resources concerning TEs in population-scale genome sequencing remains. Herein, we analyze whole-genome sequencing data sourced from the Korean Genome and Epidemiology Study, encompassing 2500 Korean individuals. To facilitate convenient data access and observation, we developed a web-based database, KTED. Additionally, we scrutinized the differential distributions of TEs across five distinct common disease groups: dyslipidemia, hypertension, diabetes, thyroid disease, and cancer. https://snubh.shinyapps.io/KTED.
ISSN:2635-0041
2635-0041
DOI:10.1093/bioadv/vbae179