Pleural irregularity, a new ultrasound sign for the study of interstitial lung disease in systemic sclerosis and antisynthetase syndrome

To evaluate a new ultrasound sign, pleural irregularity (PI), for the study of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) and antisynthetase syndrome (ASS). The study included patients from our SSc and ASS cohorts with varying degrees of ILD, enrolled from 2011 to 2014...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2015-07, Vol.33 (4 Suppl 91), p.S136-S141
Main Authors: Pinal-Fernandez, Iago, Pallisa-Nuñez, Esther, Selva-O'Callaghan, Albert, Castella-Fierro, Eva, Simeon-Aznar, Carmen Pilar, Fonollosa-Pla, Vicent, Vilardell-Tarres, Miquel
Format: Article
Language:English
Subjects:
Adult
Aged
Algorithms
Female
Humans
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - physiopathology
Male
Middle Aged
Myositis - complications
Myositis - diagnosis
Pleura - diagnostic imaging
Predictive Value of Tests
Reproducibility of Results
Respiratory Function Tests
Scleroderma, Systemic - complications
Scleroderma, Systemic - diagnosis
Serologic Tests
Tomography, X-Ray Computed
Ultrasonography
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Summary:To evaluate a new ultrasound sign, pleural irregularity (PI), for the study of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) and antisynthetase syndrome (ASS). The study included patients from our SSc and ASS cohorts with varying degrees of ILD, enrolled from 2011 to 2014. Chest high-resolution computed tomography (HRCT), pulmonary function tests (FVC and DLCO) and chest sonography were performed in each patient. Ultrasound PI and B-lines were quantified using a 72-sonographic point score and HRCT lung abnormalities were quantified using Warrick and Wells scores and categorised through Goh's algorithm. PI was correlated with HRCT and pulmonary function test parameters and its diagnostic performance to detect and classify the extent of ILD was evaluated and compared with B-lines. Thirty-seven patients were studied, 21 with ASS and 16 with SSc (8 without ILD). PI correlated with the Warrick score both in SSc (r=0.6, p=0.01) and ASS patients (r=0.6, p=0.005), showing a higher performance to detect ILD than using B-lines (p=0.01). In SSc patients PI also correlated with Wells score (r=0.7, p
ISSN:0392-856X
1593-098X