Preparation and Evaluation of the Effectiveness of an Anti-Wrinkle Cream Containing Equisetum arvense and Soybean Extracts

Skin aging is a multifaceted condition marked by the development of wrinkles, reduced suppleness, and uneven pigmentation. Both endogenous and exogenous factors contribute to skin aging. Studies have examined the possible anti-aging advantages of horsetail and soybean extracts, which are abundant in...

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Bibliographic Details
Published in:Journal of cosmetic dermatology 2025-01, Vol.24 (1), p.e16734
Main Authors: Nojomi, Sara, Soltanmohammadi, Fatemeh, Azimi Alamdari, Hamideh, Hamedyazdan, Sanaz, Mahmoudi Gharehbaba, Adel, Javadzadeh, Yousef
Format: Article
Language:English
Subjects:
Adult
Equisetum - chemistry
Female
Forehead
Glycine max - chemistry
Humans
Male
Middle Aged
Original
Phytotherapy
Pilot Projects
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Prospective Studies
Skin Aging - drug effects
Skin Cream - administration & dosage
Treatment Outcome
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Summary:Skin aging is a multifaceted condition marked by the development of wrinkles, reduced suppleness, and uneven pigmentation. Both endogenous and exogenous factors contribute to skin aging. Studies have examined the possible anti-aging advantages of horsetail and soybean extracts, which are abundant in antioxidants. A study was conducted to develop and assess the stability of an anti-wrinkle cream combining horsetail and soybean extracts over a period of 6 months. This study was a pilot study that was prospective and noncomparative in nature. An investigation was performed to explore the efficiency of a treatment on wrinkles on the forehead. The study involved 15 volunteers between the ages of 35 and 55, and the modified Fitzpatrick wrinkle grading scale (FWS) method was used to assess the results. The participants were directed to administer cream to the forehead region for a duration of eight sequential weeks. Images were acquired at the initial stage and after 8 weeks of treatment. An independent investigator evaluated the improvement in the overall appearance of the forehead skin by comparing clinical images taken before and after the therapy. The cream exhibited exceptional stability, showing no noteworthy alterations in pH, viscosity, or microbiological count. The clinical findings demonstrated a notable decrease in the average FWS score from 8.7 ± 1.3 to 6.1 ± 1.8 (p 
ISSN:1473-2130
1473-2165
1473-2165
DOI:10.1111/jocd.16734