Changes in swallowing response on patients undergoing chemoradiotherapy for head and neck cancer

Purpose Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, and persists for a few weeks thereafter. Thus, understanding the changes in swallowing physiology during and immediately...

Full description

Saved in:
Bibliographic Details
Published in:Supportive care in cancer 2025-02, Vol.33 (2), p.97, Article 97
Main Authors: Hashida, Nao, Suzuki, Motoyuki, Hosokawa, Kiyohito, Takenaka, Yukinori, Fukusumi, Takahito, Takemoto, Norihiko, Tanaka, Hidenori, Kitamura, Koji, Eguchi, Hirotaka, Umatani, Masanori, Kitayama, Itsuki, Nozawa, Masayuki, Kato, Chieri, Okajima, Eri, Inohara, Hidenori
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemoradiotherapy - adverse effects
Chemoradiotherapy - methods
Chemotherapy
Deglutition - physiology
Deglutition Disorders - etiology
Dysphagia
Female
Head & neck cancer
Head and Neck Neoplasms - therapy
Humans
Larynx
Male
Medicine
Medicine & Public Health
Middle Aged
Narcotics
Neoplasm Staging
Nursing
Nursing Research
Oncology
Pain Medicine
Radiation therapy
Rehabilitation Medicine
Retrospective Studies
Swallowing
Time Factors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, and persists for a few weeks thereafter. Thus, understanding the changes in swallowing physiology during and immediately after CRT is essential. This study aimed to clarify the changes in the swallowing response during and early after CRT and identify associated factors. Methods This retrospective study enrolled 107 patients with HNC who underwent CRT. We measured pharyngeal delay time (PDT) and laryngeal elevation delay time (LEDT) as indicators of the timing of the swallowing response at three time points: at CRT initiation (baseline), at 40-Gy irradiation during CRT (mid-CRT) and within 2 weeks following the completion of CRT (early post-CRT) as primary outcomes; and subgroup analyses based on clinical parameters, such as tumor sites, T stage, N stage, and opioid use at 40-Gy irradiation as secondary outcomes. Results Both PDT and LEDT were significantly prolonged between baseline and mid-CRT (PDT: p  = 0.003, LEDT: p  = 0.002) and between baseline and early post-CRT (PDT, p  = 0.001; LEDT, p  
ISSN:0941-4355
1433-7339
1433-7339
DOI:10.1007/s00520-024-09134-6