A recessive circadian clock mutation at the FRQ locus of Neurospora crassa

A circadian clock mutant of Neurospora crassa, the most distinctive characteristic of which is the complete loss of temperature compensation of its period length, maps to the frq locus where seven other clock mutants have previously been mapped. This mutant, designated frq-9, is recessive to the wil...

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Bibliographic Details
Published in:Genetics (Austin) 1986-12, Vol.114 (4), p.1095-1110
Main Authors: Loros, J.J, Richman, A, Feldman, J.F
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
BIOLOGICAL RHYTHMS
CHAMPIGNON
CHROMOSOME
CHROMOSOMES
Circadian Rhythm
Classical genetics, quantitative genetics, hybrids
CROMOSOMAS
Crosses, Genetic
Fundamental and applied biological sciences. Psychology
FUNGI
GENE
GENE RECESSIF
GENES
GENES RECESIVOS
Genes, Fungal
Genes, Recessive
Genetic Linkage
Genetics of eukaryotes. Biological and molecular evolution
Investigations
MUTACION
MUTATION
Neurospora - genetics
Neurospora crassa
Neurospora crassa - genetics
RECESSIVE GENES
RITMOS BIOLOGICOS
RYTHME BIOLOGIQUE
Temperature
Thallophyta, bryophyta
Vegetals
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Description
Summary:A circadian clock mutant of Neurospora crassa, the most distinctive characteristic of which is the complete loss of temperature compensation of its period length, maps to the frq locus where seven other clock mutants have previously been mapped. This mutant, designated frq-9, is recessive to the wild-type allele and to each of the other frq mutants; thus, it differs from the other mutants, which show incomplete dominance to wild type and to each other. Complementation analysis suggests either that the frq locus is a single gene or that frq-9 is a deletion that overlaps adjacent genes. Preliminary efforts at fine structure mapping have indicated that recombination between certain pairs of frq mutations is less than 0.005%, a distance consistent with the locus being a single gene. The recessive nature of frq-9, coupled with complete loss of temperature compensation, suggests that this mutant may represent the null phenotype of the locus and that the frq gene is involved in the temperature compensation mechanism of the clock.--Genetic mapping studies have placed the frq locus on linkage group VIIR, midway between oli (oligomycin resistance) and for (formate auxotrophy), about 2 map units from each, and clearly indicate that frq and oli are separate genes.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/114.4.1095