Age-specific patterns of genetic variance in Drosophila melanogaster. II. Fecundity and its genetic covariance with age-specific mortality

Under the mutation accumulation model of senescence, it was predicted that the additive genetic variance (VA) for fitness traits will increase with age. We measured age-specific mortality and fecundity from 65,134 Drosophila melanogaster and estimated genetic variance components, based on reciprocal...

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Bibliographic Details
Published in:Genetics (Austin) 1996-06, Vol.143 (2), p.849-858
Main Authors: Tatar, M. (University of Minnesota, St. Paul, MN.), Promislow, D.E.L, Khazaeli, A.A, Curtsinger, J.W
Format: Article
Language:English
Subjects:
AGE
Aging - genetics
Animals
CORRELACION GENETICA
CORRELATION GENETIQUE
COVARIANCE GENETIQUE
COVARIANZA GENETICA
DROSOPHILA MELANOGASTER
Drosophila melanogaster - genetics
EDAD
FERTILIDAD
FERTILITE
Fertility
GENETICA
Genetics
GENETIQUE
Investigations
MORTALIDAD
MORTALITE
Mortality
MUTACION
MUTATION
PARAMETRE GENETIQUE
PARAMETROS GENETICOS
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Summary:Under the mutation accumulation model of senescence, it was predicted that the additive genetic variance (VA) for fitness traits will increase with age. We measured age-specific mortality and fecundity from 65,134 Drosophila melanogaster and estimated genetic variance components, based on reciprocal crosses of extracted second chromosome lines. Elsewhere we report the results for mortality. Here, for fecundity, we report a bimodal pattern for VA with peaks at 3 days and at 17-31 days. Under the antagonistic pleiotropy model of senescence, it was predicted that negative correlations will exist between early and late life history traits. For fecundity itself we find positive genetic correlations among age classes 3 days but negative nonsignificant correlations between fecundity at 3 days and at older age classes. For fecundity vs. age-specific mortality, we find positive fitness correlations (negative genetic correlations) among the traits at all ages 3 days but a negative fitness correlation between fecundity at 3 days and mortality at the oldest ages (positive genetic correlations ). For age-specific mortality itself we find overwhelmingly positive genetic correlations among all age classes. The data suggest that mutation accumulation may be a major source of standing genetic variance for senescence
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/143.2.849