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Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development
This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. Th...
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| Published in: | Genetics (Austin) 1996-11, Vol.144 (3), p.991-1003 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_start_page | 991 |
| container_title | Genetics (Austin) |
| container_volume | 144 |
| creator | Aramayo, R. (Stanford University, Stanford, CA.) Peleg, Y Addison, R Metzenberg, R |
| description | This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development |
| doi_str_mv | 10.1093/genetics/144.3.991 |
| format | article |
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(Stanford University, Stanford, CA.) ; Peleg, Y ; Addison, R ; Metzenberg, R</creator><creatorcontrib>Aramayo, R. (Stanford University, Stanford, CA.) ; Peleg, Y ; Addison, R ; Metzenberg, R</creatorcontrib><description>This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1093/genetics/144.3.991</identifier><identifier>PMID: 8913744</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>ADN ; Amino Acid Sequence ; Base Sequence ; Cell Nucleus - metabolism ; CLONACION ; CLONAGE ; Cloning, Molecular ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; DIFERENCIACION CELULAR ; DIFFERENCIATION CELLULAIRE ; DNA, Fungal ; ESPORAS ; ESPORAS FUNGICAS ; EXPRESION GENICA ; EXPRESSION DES GENES ; FENOTIPOS ; Fungal Proteins ; Fungi ; Gene Deletion ; Gene Expression Regulation, Fungal ; Genes, Regulator ; GENETICA ; Genetics ; GENETIQUE ; GERMINACION ; GERMINATION ; IMMUNOLOGIE ; INMUNOLOGIA ; Investigations ; MARCADORES GENETICOS ; MARQUEUR GENETIQUE ; Molecular biology ; Molecular Sequence Data ; MORFOLOGIA FUNGICA ; MORPHOLOGIE DE CHAMPIGNON ; MUTANT ; MUTANTES ; NEUROSPORA CRASSA ; Neurospora crassa - genetics ; Neurospora crassa - growth & development ; PHENOTYPE ; PROTEINAS AGLUTINANTES ; PROTEINE DE LIAISON ; Proteins ; RFLP ; SECUENCIA NUCLEOTIDICA ; Sequence Homology, Amino Acid ; SEQUENCE NUCLEOTIDIQUE ; SPORE ; SPORE FONGIQUE ; TRANSCRIPCION ; TRANSCRIPTION ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic</subject><ispartof>Genetics (Austin), 1996-11, Vol.144 (3), p.991-1003</ispartof><rights>Copyright Genetics Society of America Nov 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9bd5b22c8659959e2ad7cb45fc2496d27e87780e7fec875f74fd265fb0b7e3e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8913744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aramayo, R. (Stanford University, Stanford, CA.)</creatorcontrib><creatorcontrib>Peleg, Y</creatorcontrib><creatorcontrib>Addison, R</creatorcontrib><creatorcontrib>Metzenberg, R</creatorcontrib><title>Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development</description><subject>ADN</subject><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Cell Nucleus - metabolism</subject><subject>CLONACION</subject><subject>CLONAGE</subject><subject>Cloning, Molecular</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>DIFERENCIACION CELULAR</subject><subject>DIFFERENCIATION CELLULAIRE</subject><subject>DNA, Fungal</subject><subject>ESPORAS</subject><subject>ESPORAS FUNGICAS</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>FENOTIPOS</subject><subject>Fungal Proteins</subject><subject>Fungi</subject><subject>Gene Deletion</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genes, Regulator</subject><subject>GENETICA</subject><subject>Genetics</subject><subject>GENETIQUE</subject><subject>GERMINACION</subject><subject>GERMINATION</subject><subject>IMMUNOLOGIE</subject><subject>INMUNOLOGIA</subject><subject>Investigations</subject><subject>MARCADORES GENETICOS</subject><subject>MARQUEUR GENETIQUE</subject><subject>Molecular biology</subject><subject>Molecular Sequence Data</subject><subject>MORFOLOGIA FUNGICA</subject><subject>MORPHOLOGIE DE CHAMPIGNON</subject><subject>MUTANT</subject><subject>MUTANTES</subject><subject>NEUROSPORA CRASSA</subject><subject>Neurospora crassa - genetics</subject><subject>Neurospora crassa - growth & development</subject><subject>PHENOTYPE</subject><subject>PROTEINAS AGLUTINANTES</subject><subject>PROTEINE DE LIAISON</subject><subject>Proteins</subject><subject>RFLP</subject><subject>SECUENCIA NUCLEOTIDICA</subject><subject>Sequence Homology, Amino Acid</subject><subject>SEQUENCE NUCLEOTIDIQUE</subject><subject>SPORE</subject><subject>SPORE FONGIQUE</subject><subject>TRANSCRIPCION</subject><subject>TRANSCRIPTION</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNpVkU1v1DAQhi0EKkvhD1RCijhwodn6K_64IFUVFKQKDtAbkuU446yrJA520hX_Hle7VOU00jzvvDP2i9AZwVuCNbvoYYIluHxBON-yrdbkGdoQzVlNBSPP0QZjImohGXmJXuV8hzEWulEn6ERpwiTnG_TrMo81-XBe2eobrCnmOSZbuWRzttWDf5VgsAt01RKrJdkpuxTmJcTJDgX1a4Ex5Sr6yq9TX5od3MMQ5xGm5TV64e2Q4c2xnqLbz59-Xn2pb75ff726vKkdl3ypdds1LaVOiUbrRgO1nXQtb7yjXIuOSlBSKgzSg1Oy8ZL7jorGt7iVwICwU_Tx4Duv7QidK6uTHcycwmjTHxNtMP-TKexMH-8NoVgKporBu6NBir9XyIu5i2sqT8yGEk4YUUIUET2IXPmmnMA_LiDYPORh_uVhSh6GmZJHGXr79LTHkWMAhb8_8F3od_uQwOTRDkNRE7Pf758anR2E3kZj-xSyuf2hJS7XKfYXwmugRA</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Aramayo, R. 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(Stanford University, Stanford, CA.) ; Peleg, Y ; Addison, R ; Metzenberg, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9bd5b22c8659959e2ad7cb45fc2496d27e87780e7fec875f74fd265fb0b7e3e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>ADN</topic><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Cell Nucleus - metabolism</topic><topic>CLONACION</topic><topic>CLONAGE</topic><topic>Cloning, Molecular</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>DIFERENCIACION CELULAR</topic><topic>DIFFERENCIATION CELLULAIRE</topic><topic>DNA, Fungal</topic><topic>ESPORAS</topic><topic>ESPORAS FUNGICAS</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>FENOTIPOS</topic><topic>Fungal Proteins</topic><topic>Fungi</topic><topic>Gene Deletion</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genes, Regulator</topic><topic>GENETICA</topic><topic>Genetics</topic><topic>GENETIQUE</topic><topic>GERMINACION</topic><topic>GERMINATION</topic><topic>IMMUNOLOGIE</topic><topic>INMUNOLOGIA</topic><topic>Investigations</topic><topic>MARCADORES GENETICOS</topic><topic>MARQUEUR GENETIQUE</topic><topic>Molecular biology</topic><topic>Molecular Sequence Data</topic><topic>MORFOLOGIA FUNGICA</topic><topic>MORPHOLOGIE DE CHAMPIGNON</topic><topic>MUTANT</topic><topic>MUTANTES</topic><topic>NEUROSPORA CRASSA</topic><topic>Neurospora crassa - genetics</topic><topic>Neurospora crassa - growth & development</topic><topic>PHENOTYPE</topic><topic>PROTEINAS AGLUTINANTES</topic><topic>PROTEINE DE LIAISON</topic><topic>Proteins</topic><topic>RFLP</topic><topic>SECUENCIA NUCLEOTIDICA</topic><topic>Sequence Homology, Amino Acid</topic><topic>SEQUENCE NUCLEOTIDIQUE</topic><topic>SPORE</topic><topic>SPORE FONGIQUE</topic><topic>TRANSCRIPCION</topic><topic>TRANSCRIPTION</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aramayo, R. 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(Stanford University, Stanford, CA.)</au><au>Peleg, Y</au><au>Addison, R</au><au>Metzenberg, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>144</volume><issue>3</issue><spage>991</spage><epage>1003</epage><pages>991-1003</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>8913744</pmid><doi>10.1093/genetics/144.3.991</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-6731 |
| ispartof | Genetics (Austin), 1996-11, Vol.144 (3), p.991-1003 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1207638 |
| source | Freely Accessible Science Journals; Oxford Journals Online; Alma/SFX Local Collection |
| subjects | ADN Amino Acid Sequence Base Sequence Cell Nucleus - metabolism CLONACION CLONAGE Cloning, Molecular COMPOSICION QUIMICA COMPOSITION CHIMIQUE DIFERENCIACION CELULAR DIFFERENCIATION CELLULAIRE DNA, Fungal ESPORAS ESPORAS FUNGICAS EXPRESION GENICA EXPRESSION DES GENES FENOTIPOS Fungal Proteins Fungi Gene Deletion Gene Expression Regulation, Fungal Genes, Regulator GENETICA Genetics GENETIQUE GERMINACION GERMINATION IMMUNOLOGIE INMUNOLOGIA Investigations MARCADORES GENETICOS MARQUEUR GENETIQUE Molecular biology Molecular Sequence Data MORFOLOGIA FUNGICA MORPHOLOGIE DE CHAMPIGNON MUTANT MUTANTES NEUROSPORA CRASSA Neurospora crassa - genetics Neurospora crassa - growth & development PHENOTYPE PROTEINAS AGLUTINANTES PROTEINE DE LIAISON Proteins RFLP SECUENCIA NUCLEOTIDICA Sequence Homology, Amino Acid SEQUENCE NUCLEOTIDIQUE SPORE SPORE FONGIQUE TRANSCRIPCION TRANSCRIPTION Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
| title | Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development |
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