Discordant Phylogeographic Patterns Between the Y Chromosome and Mitochondrial DNA in the House Mouse: Selection on the Y Chromosome?

We have compared patterns of geographic variation and molecular divergence of mitochondrial DNA (mtDNA) and Y chromosome over the range of the different subspecies of Mus musculus. MtDNA was typed for 305 nucleotides in the control region, the Y chromosome for 834 base pairs (bp) in Zfy introns and...

Full description

Saved in:
Bibliographic Details
Published in:Genetics (Austin) 1997-07, Vol.146 (3), p.1019-1034
Main Authors: Boissinot, S, Boursot, P
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological Evolution
Deoxyribonucleic acid
DNA
DNA, Mitochondrial
DNA-Binding Proteins - genetics
Genetic Variation
Genetics
Introns
Investigations
Male
Mice - classification
Mice - genetics
Microsatellite Repeats
Molecular Sequence Data
Mus musculus
Nuclear Proteins
Phylogeny
Rodents
Sequence Homology, Nucleic Acid
Sex-Determining Region Y Protein
Transcription Factors
Y Chromosome
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have compared patterns of geographic variation and molecular divergence of mitochondrial DNA (mtDNA) and Y chromosome over the range of the different subspecies of Mus musculus. MtDNA was typed for 305 nucleotides in the control region, the Y chromosome for 834 base pairs (bp) in Zfy introns and 242 bp in Sry, a Zfy2 18-bp deletion, and two microsatellites. Apparent discrepancies exist between the distributions of the lineages of mtDNA and of the two major Y-chromosome lineages thus defined: some subspecies share the same mtDNA lineage but have different Y-chromosome lineages or vice versa. One microsatellite reveals a geographically clustered variation inside the distribution of each Y-chromosome lineage, showing that new Y-chromosome variants can rapidly spread locally. The two major Y-chromosome lineages have a divergence time only about one fourth of that between mtDNA lineages. Although this recent coalescence of the Y chromosomes between subspecies could partly be due to a lower ancestral polymorphism of the Y chromosome, it suggests that secondary introgression after the radiation of the subspecies might have occurred. There is evidence that the differentiation of the Y-chromosome lineages contributes to partial reproductive isolation between subspecies, and patterns of molecular evolution suggest that selection has played a role in the rapid spread across subspecies.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/146.3.1019