Nonheartbeating cadaveric organ donation

The authors evaluated the potential use of nonheartbeating (NHB) cadaver donors as an additional source to the current supply of brain-dead cadaver donors. The numbers of cadaveric donors has not increased significantly during the last 5 years, despite a rising need for transplantable organs. Any im...

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Bibliographic Details
Published in:Annals of surgery 1994-10, Vol.220 (4), p.578-585
Main Authors: Orloff, M S, Reed, A I, Erturk, E, Kruk, R A, Paprocki, S A, Cimbalo, S C, Cerilli, G J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain Death
Cadaver
Child
Graft Survival - physiology
Humans
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - surgery
Kidney Transplantation - methods
Kidney Transplantation - physiology
Postoperative Care
Renal Dialysis
Survival Rate
Tissue and Organ Procurement - methods
Tissue Donors - supply & distribution
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Summary:The authors evaluated the potential use of nonheartbeating (NHB) cadaver donors as an additional source to the current supply of brain-dead cadaver donors. The numbers of cadaveric donors has not increased significantly during the last 5 years, despite a rising need for transplantable organs. Any improvement in cadaveric organ procurement will depend on the use of previously unrecognized potential donors. During a 2-year period, 24 kidneys were retrieved from 12 NHB donors. Nineteen kidneys were transplanted. These kidneys sustained a mean warm ischemia time of 26 minutes (range 20-35 min). A mean lowest creatinine level of 2.0 mg/dL, (range 1.1-3.0 mg/dL), the rate of postoperative dialysis (22%), and a 1-year graft survival rate of 76% for kidneys from NHB-donated kidneys compare favorably to expected results achieved nationally from brain-dead cadaveric donors. Nonheartbeating donor kidneys can yield acceptable graft function and be of no disadvantage to recipients of cadaver transplants.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-199410000-00016