Control of canine renin release: macula densa requires prostaglandin synthesis

1. The macula densa mechanism of renin release was functionally isolated in uninephrectomized, anaesthetized dogs by producing renal denervation, beta-adrenoceptor blockade, and maximum renal vasodilation with an infusion of papaverine into the renal artery. 2. A suprarenal aortic clamp was adjusted...

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Bibliographic Details
Published in:The Journal of physiology 1981-01, Vol.319 (1), p.419-429
Main Authors: Gerber, J G, Nies, A S, Olsen, R D
Format: Article
Language:English
Subjects:
Animals
Cyclooxygenase Inhibitors
Dogs
Female
Indomethacin - pharmacology
Kidney Tubules - metabolism
Kidney Tubules, Distal - metabolism
Male
Meclofenamic Acid - pharmacology
Natriuresis - drug effects
Prostaglandins - biosynthesis
Renin - blood
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Summary:1. The macula densa mechanism of renin release was functionally isolated in uninephrectomized, anaesthetized dogs by producing renal denervation, beta-adrenoceptor blockade, and maximum renal vasodilation with an infusion of papaverine into the renal artery. 2. A suprarenal aortic clamp was adjusted to reduce renal perfusion pressure by 50% which resulted in a 90% reduction in urinary sodium excretion and a two to threefold increase in plasma renin activity within 10 min. 3. Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved. 4. We conclude that the macula densa mechanism of renin release is blocked by inhibition of prostaglandin synthesis.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1981.sp013918