The precursors of the xylene ring in riboflavine

1. The nature of the precursors of the xylene ring in riboflavine was reinvestigated with growing as well as resting cells of Eremothecium ashbyii. 2. The incorporation of acetoin into riboflavine was very low; further, [2-(14)C]pyruvate and [1-(14)C]acetate were equally effective as precursors of l...

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Bibliographic Details
Published in:Biochemical journal 1966-01, Vol.98 (1), p.182-188
Main Authors: Ali, S N, al-Khalidi, U A
Format: Article
Language:English
Subjects:
Acetates - metabolism
Ascomycota - metabolism
Flavins
Glucose - pharmacology
In Vitro Techniques
Ketones - metabolism
Pyruvates - metabolism
Riboflavin - biosynthesis
Xylenes - biosynthesis
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Summary:1. The nature of the precursors of the xylene ring in riboflavine was reinvestigated with growing as well as resting cells of Eremothecium ashbyii. 2. The incorporation of acetoin into riboflavine was very low; further, [2-(14)C]pyruvate and [1-(14)C]acetate were equally effective as precursors of lumichrome, and pyruvate was much more active as a precursor of acetoin. These results exclude acetoin as a direct precursor of riboflavine. 3. Addition of unlabelled glucose decreased the incorporation of [(14)C]acetate into riboflavine more than it decreased the conversion of acetate into carbon dioxide, indicating that acetate is not a direct riboflavine precursor. 4. The incorporation of various sugars and dilution experiments suggest that a derivative of the intermediates of the pentose phosphate cycle is the precursor of the xylene ring in riboflavine.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj0980182