Glycolytic activation of β-cell Na+/K+-ATPases containing β1-subunits accelerates Na+ extrusion, prolonging the duration of Ca2+ oscillations but decreasing insulin secretion

Electrogenic Na+/K+ ATPases (NKAs) control β-cell Ca2+ influx and insulin secretion by integrating the signal strength of stimulatory G protein (Gs)-coupled ligands (e.g., GLP-1, glucagon) and inhibitory G protein (Gi)-coupled ligands (e.g., somatostatin, epinephrine). However, there is a significan...

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Bibliographic Details
Published in:Molecular metabolism (Germany) 2026-01, Vol.103, p.102296, Article 102296
Main Authors: Dickerson, Matthew T., Dadi, Prasanna K., McDevitt, Reagan P., Dobson, Jordyn R., Behera, Soma, Peachee, Spencer J., Gibson, Shannon E., Wangmo, Tenzin, Jacobson, David A.
Format: Article
Language:English
Subjects:
Calcium oscillations
G protein-coupled receptor signaling
Glucose-stimulated insulin secretion
Membrane excitability
Original
Pancreatic beta-cells
Sodium/potassium ATPase
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